Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Jurriën Collet, Thomas Roose, Bram Weijers, Bert Maes*, Eelco Ruijter*, Romano Orrù*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C-1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.
Original languageEnglish
Article number4906
Number of pages52
JournalMolecules
Volume25
Issue number21
DOIs
Publication statusPublished - 23 Oct 2020

Keywords

  • isocyanides
  • palladium
  • insertion reactions
  • heterocycles
  • catalysis
  • TERT-BUTYL ISOCYANIDE
  • ONE-POT SYNTHESIS
  • ARYL HALIDES
  • LIVING POLYMERIZATION
  • CASCADE REACTIONS
  • IMIDOYLATIVE CYCLIZATION
  • NITROGEN-HETEROCYCLES
  • MIGRATORY INSERTION
  • COUPLING REACTIONS
  • ARYLBORONIC ACIDS

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