Recent Advances in Molecularly Imprinted Polymers for Glucose Monitoring: From Fundamental Research to Commercial Application

M. Caldara*, J. Kulpa, J.W. Lowdon, T.J. Cleij, H. Dilien, K. Eersels, B. van Grinsven

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Molecularly imprinted polymers (MIPs) have gained growing interest among researchers worldwide, due to their key features that make these materials interesting candidates for implementation as receptors into sensor applications. In fact, MIP-based glucose sensors could overcome the stability issues associated with the enzymes present in commercial glucose devices. Various reports describe the successful development of glucose MIPs and their coupling to a wide variety of transducers for creating sensors that are able to detect glucose in various matrices. In this review, we have summarized and critically evaluated the different production methods of glucose MIPs and the different transducer technologies used in MIP-based glucose sensors, and analyzed these from a commercial point of view. In this way, this review sets out to highlight the most promising approaches in MIP-based sensing in terms of both manufacturing methods and readout technologies employed. In doing so, we aim at delineating potential future approaches and identifying potential obstacles that the MIP-sensing field may encounter in an attempt to penetrate the commercial, analytical market.
Original languageEnglish
Article number32
Number of pages24
JournalChemosensors
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2023

Keywords

  • glucose sensing
  • molecularly imprinted polymers
  • artificial receptors
  • glucose monitoring
  • non-enzymatic glucose sensors
  • clinical analysis
  • health diagnostics
  • ELECTROCHEMICAL GLUCOSE
  • SENSOR
  • NANOPARTICLES
  • SEPARATION
  • TEMPLATE
  • POLYMERIZATION
  • PERSPECTIVES
  • TECHNOLOGY
  • EXTRACTION
  • BIOSENSORS

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