Recent Advancements in Regenerative Approaches for Thymus Rejuvenation

H. Sharma, L. Moroni*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

2 Citations (Web of Science)

Abstract

The thymus plays a key role in adaptive immunity by generating a diverse population of T cells that defend the body against pathogens. Various factors from disease and toxic insults contribute to the degeneration of the thymus resulting in a fewer output of T cells. Consequently, the body is prone to a wide host of diseases and infections. In this review, first, the relevance of the thymus is discussed, followed by thymic embryological organogenesis and anatomy as well as the development and functionality of T cells. Attempts to regenerate the thymus include in vitro methods, such as forming thymic organoids aided by biofabrication techniques that are transplantable. Ex vivo methods that have shown promise in enhancing thymic regeneration are also discussed. Current regenerative technologies have not yet matched the complexity and functionality of the thymus. Therefore, emerging techniques that have shown promise and the challenges that lie ahead are explored.
Original languageEnglish
Article number2100543
Number of pages22
JournalAdvanced Science
Volume8
Issue number14
DOIs
Publication statusPublished - 1 Jul 2021

Keywords

  • biofabrication
  • immune reconstitution
  • organoids
  • stem cells
  • T&#160
  • cells
  • thymus regeneration
  • T-CELL DEVELOPMENT
  • PLURIPOTENT STEM-CELLS
  • VERSUS-HOST-DISEASE
  • LONG-TERM EXPANSION
  • EPITHELIAL-CELLS
  • HEMATOPOIETIC STEM
  • IN-VITRO
  • PROGENITOR CELLS
  • BONE-MARROW
  • EXTRACELLULAR-MATRIX

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