Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation

Bart Maesen; Stef Zeemering; Carlos Afonso; Jens Eckstein; Rebecca A. B. Burton; Arne van Hunnik; Daniel J. Stuckey; Damian Tyler; Jos Maessen; Vicente Grau; Sander Verheule; Peter Kohl; Ulrich Schotten

doi:10.1161/CIRCEP.113.000050

Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation

Bart Maesen, Stef Zeemering, Carlos Afonso, Jens Eckstein, Rebecca A. B. Burton, Arne van Hunnik, Daniel J. Stuckey, Damian Tyler, Jos Maessen, Vicente Grau, Sander Verheule, Peter Kohl, Ulrich Schotten^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Anisotropy of conduction facilitates re-entry and is, therefore, a key determinant of the stability of atrial fibrillation (AF). Little is known about the effect of AF on atrial bundle architecture and consequent changes in anisotropy of conduction and maintenance of AF. Methods and Results Direct contact mapping was performed in left atria of goats with acute AF (n=6) or persistent AF (n=5). The degree and direction of anisotropic conduction were analyzed. Mapped tissue regions were imaged by high-resolution MRI for identification of endocardial and epicardial bundle directions. Correlation between endocardial and epicardial bundle directions and between bundle directions and anisotropic conduction was quantified. In persistent AF, epicardial bundles were oriented more perpendicularly to endocardial bundles than in acute AF (% angles

Original language	English
Pages (from-to)	967-975
Journal	Circulation-Arrhythmia and Electrophysiology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1161/CIRCEP.113.000050
Publication status	Published - Oct 2013

Keywords

arrhythmia
atrial fibrillation
electrical dissociation
electrophysiology
epicardial mapping
remodeling

Access to Document

10.1161/CIRCEP.113.000050

Cite this

Maesen, B., Zeemering, S., Afonso, C., Eckstein, J., Burton, R. A. B., van Hunnik, A., Stuckey, D. J., Tyler, D., Maessen, J., Grau, V., Verheule, S., Kohl, P., & Schotten, U. (2013). Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation. Circulation-Arrhythmia and Electrophysiology, 6(5), 967-975. https://doi.org/10.1161/CIRCEP.113.000050

@article{2736b4d5527a4855aed40da6d993a1ef,

title = "Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation",

abstract = "Background Anisotropy of conduction facilitates re-entry and is, therefore, a key determinant of the stability of atrial fibrillation (AF). Little is known about the effect of AF on atrial bundle architecture and consequent changes in anisotropy of conduction and maintenance of AF. Methods and Results Direct contact mapping was performed in left atria of goats with acute AF (n=6) or persistent AF (n=5). The degree and direction of anisotropic conduction were analyzed. Mapped tissue regions were imaged by high-resolution MRI for identification of endocardial and epicardial bundle directions. Correlation between endocardial and epicardial bundle directions and between bundle directions and anisotropic conduction was quantified. In persistent AF, epicardial bundles were oriented more perpendicularly to endocardial bundles than in acute AF (% angles ",

keywords = "arrhythmia, atrial fibrillation, electrical dissociation, electrophysiology, epicardial mapping, remodeling",

author = "Bart Maesen and Stef Zeemering and Carlos Afonso and Jens Eckstein and Burton, {Rebecca A. B.} and {van Hunnik}, Arne and Stuckey, {Daniel J.} and Damian Tyler and Jos Maessen and Vicente Grau and Sander Verheule and Peter Kohl and Ulrich Schotten",

year = "2013",

month = oct,

doi = "10.1161/CIRCEP.113.000050",

language = "English",

volume = "6",

pages = "967--975",

journal = "Circulation-Arrhythmia and Electrophysiology",

issn = "1941-3149",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "5",

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Maesen, B , Zeemering, S, Afonso, C, Eckstein, J, Burton, RAB, van Hunnik, A, Stuckey, DJ, Tyler, D, Maessen, J, Grau, V, Verheule, S, Kohl, P & Schotten, U 2013, 'Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation', Circulation-Arrhythmia and Electrophysiology, vol. 6, no. 5, pp. 967-975. https://doi.org/10.1161/CIRCEP.113.000050

Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation. / Maesen, Bart ; Zeemering, Stef; Afonso, Carlos et al.
In: Circulation-Arrhythmia and Electrophysiology, Vol. 6, No. 5, 10.2013, p. 967-975.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation

AU - Maesen, Bart

AU - Zeemering, Stef

AU - Afonso, Carlos

AU - Eckstein, Jens

AU - Burton, Rebecca A. B.

AU - van Hunnik, Arne

AU - Stuckey, Daniel J.

AU - Tyler, Damian

AU - Maessen, Jos

AU - Grau, Vicente

AU - Verheule, Sander

AU - Kohl, Peter

AU - Schotten, Ulrich

PY - 2013/10

Y1 - 2013/10

N2 - Background Anisotropy of conduction facilitates re-entry and is, therefore, a key determinant of the stability of atrial fibrillation (AF). Little is known about the effect of AF on atrial bundle architecture and consequent changes in anisotropy of conduction and maintenance of AF. Methods and Results Direct contact mapping was performed in left atria of goats with acute AF (n=6) or persistent AF (n=5). The degree and direction of anisotropic conduction were analyzed. Mapped tissue regions were imaged by high-resolution MRI for identification of endocardial and epicardial bundle directions. Correlation between endocardial and epicardial bundle directions and between bundle directions and anisotropic conduction was quantified. In persistent AF, epicardial bundles were oriented more perpendicularly to endocardial bundles than in acute AF (% angles

AB - Background Anisotropy of conduction facilitates re-entry and is, therefore, a key determinant of the stability of atrial fibrillation (AF). Little is known about the effect of AF on atrial bundle architecture and consequent changes in anisotropy of conduction and maintenance of AF. Methods and Results Direct contact mapping was performed in left atria of goats with acute AF (n=6) or persistent AF (n=5). The degree and direction of anisotropic conduction were analyzed. Mapped tissue regions were imaged by high-resolution MRI for identification of endocardial and epicardial bundle directions. Correlation between endocardial and epicardial bundle directions and between bundle directions and anisotropic conduction was quantified. In persistent AF, epicardial bundles were oriented more perpendicularly to endocardial bundles than in acute AF (% angles

KW - arrhythmia

KW - atrial fibrillation

KW - electrical dissociation

KW - electrophysiology

KW - epicardial mapping

KW - remodeling

U2 - 10.1161/CIRCEP.113.000050

DO - 10.1161/CIRCEP.113.000050

M3 - Article

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SN - 1941-3149

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JO - Circulation-Arrhythmia and Electrophysiology

JF - Circulation-Arrhythmia and Electrophysiology

IS - 5

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