'Real-world' observational studies in arrhythmia research: data sources, methodology, and interpretation. A position document from European Heart Rhythm Association (EHRA), endorsed by Heart Rhythm Society (HRS), Asia-Pacific HRS (APHRS), and Latin America HRS (LAHRS)

C. Torp-Pedersen*, A. Goette, P.B. Nielsen, T. Potpara, L. Fauchier, A.J. Camm, E. Arbelo, G. Boriani, F. Skjoeth, J. Rumsfeld, F. Masoudi, Y.T. Guo, B. Joung, M.M. Refaat, Y.H. Kim, C.M. Albert, J. Piccini, A. Avezum, G.Y.H. Lip, B. GorenekN. Dagres, F. Violi, X. Du, M. Akao, E.K. Choi, R.D. Lopes, E.E. Ozcan, D. Lane, F. Marin, C.P. Gale, K. Vernooy, G. Kudaiberdieva, V. Kutyifa, V.B. Traykov, C. Guevara, T.F. Chao, S.M. Al-Khatib

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Web of Science)

Abstract

The field of observational studies or "real world studies" is in rapid development with many new techniques introduced and increased understanding of traditional methods. For this reason the current paper provides an overview of current methods with focus on new techniques. Some highlights can be emphasized: We provide an overview of sources of data for observational studies. There is an overview of sources of bias and confounding. Next There is an overview of causal inference techniques that are increasingly used. The most commonly used techniques for statistical modelling are reviewed with focus on the important distinction of risk versus prediction. The final section provides examples of common problems with reporting observational data.
Original languageEnglish
Pages (from-to)831-832
Number of pages13
JournalEP Europace
Volume22
Issue number5
DOIs
Publication statusPublished - 1 May 2020

Keywords

  • adverse outcomes
  • ambulatory blood-pressure
  • arrhythmias
  • atrial fibrillation
  • atrial-fibrillation patients
  • cha(2)ds(2)-vasc score
  • database
  • ehra position paper
  • epidemiological study
  • european heart rhythm association
  • extension statement
  • intracranial hemorrhage
  • meta-analysis
  • methodology
  • nationwide cohort
  • oral anticoagulants
  • randomized controlled-trials
  • real-world observational study
  • registry
  • reporting characteristics
  • systematic reviews
  • EHRA position paper
  • SYSTEMATIC REVIEWS
  • Methodology
  • ADVERSE OUTCOMES
  • Epidemiological study
  • INTRACRANIAL HEMORRHAGE
  • Nationwide cohort
  • REPORTING CHARACTERISTICS
  • ORAL ANTICOAGULANTS
  • European Heart Rhythm Association
  • Database
  • RANDOMIZED CONTROLLED-TRIALS
  • Atrial fibrillation
  • Registry
  • ATRIAL-FIBRILLATION PATIENTS
  • Meta-analysis
  • EXTENSION STATEMENT
  • Real-world observational study
  • CHA(2)DS(2)-VASC SCORE
  • Arrhythmias
  • AMBULATORY BLOOD-PRESSURE

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