Rational modulator design by exploitation of protein-protein complex structures

Kanin Wichapong; Hessel Poelman; Bogac Ercig; Johana Hrdinova; Xiaosong Liu; Esther Lutgens; Gerry A. F. Nicolaes

doi:10.4155/fmc-2018-0433

Rational modulator design by exploitation of protein-protein complex structures

Kanin Wichapong, Hessel Poelman, Bogac Ercig, Johana Hrdinova, Xiaosong Liu, Esther Lutgens, Gerry A. F. Nicolaes^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

Original language	English
Pages (from-to)	1015-1033
Number of pages	19
Journal	Future Medicinal Chemistry
Volume	11
Issue number	9
DOIs	https://doi.org/10.4155/fmc-2018-0433
Publication status	Published - May 2019

Keywords

intrinsically disordered proteins
peptide design
peptidomimetics
PPI modulators
protein-protein interactions
MOLECULAR-DYNAMICS SIMULATIONS
INTRINSICALLY DISORDERED PROTEINS
SELECTIVE SMALL-MOLECULE
PARTICLE CRYO-EM
DRUG DISCOVERY
IN-SILICO
MASS-SPECTROMETRY
BINDING-SITES
WEB SERVER
C-MYC

Access to Document

10.4155/fmc-2018-0433

Cite this

Wichapong, K., Poelman, H., Ercig, B., Hrdinova, J., Liu, X., Lutgens, E., & Nicolaes, G. A. F. (2019). Rational modulator design by exploitation of protein-protein complex structures. Future Medicinal Chemistry, 11(9), 1015-1033. https://doi.org/10.4155/fmc-2018-0433

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title = "Rational modulator design by exploitation of protein-protein complex structures",

keywords = "intrinsically disordered proteins, peptide design, peptidomimetics, PPI modulators, protein-protein interactions, MOLECULAR-DYNAMICS SIMULATIONS, INTRINSICALLY DISORDERED PROTEINS, SELECTIVE SMALL-MOLECULE, PARTICLE CRYO-EM, DRUG DISCOVERY, IN-SILICO, MASS-SPECTROMETRY, BINDING-SITES, WEB SERVER, C-MYC",

author = "Kanin Wichapong and Hessel Poelman and Bogac Ercig and Johana Hrdinova and Xiaosong Liu and Esther Lutgens and Nicolaes, {Gerry A. F.}",

year = "2019",

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doi = "10.4155/fmc-2018-0433",

language = "English",

volume = "11",

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T1 - Rational modulator design by exploitation of protein-protein complex structures

AU - Wichapong, Kanin

AU - Poelman, Hessel

AU - Ercig, Bogac

AU - Hrdinova, Johana

AU - Liu, Xiaosong

AU - Lutgens, Esther

AU - Nicolaes, Gerry A. F.

PY - 2019/5

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KW - peptide design

KW - peptidomimetics

KW - PPI modulators

KW - protein-protein interactions

KW - MOLECULAR-DYNAMICS SIMULATIONS

KW - INTRINSICALLY DISORDERED PROTEINS

KW - SELECTIVE SMALL-MOLECULE

KW - PARTICLE CRYO-EM

KW - DRUG DISCOVERY

KW - IN-SILICO

KW - MASS-SPECTROMETRY

KW - BINDING-SITES

KW - WEB SERVER

KW - C-MYC

U2 - 10.4155/fmc-2018-0433

DO - 10.4155/fmc-2018-0433

M3 - Review article

VL - 11

SP - 1015

EP - 1033

JO - Future Medicinal Chemistry

JF - Future Medicinal Chemistry

SN - 1756-8919

IS - 9

ER -