RATEmiRs: the rat atlas of tissue-specific and enriched miRNAs for discerning baseline expression exclusivity of candidate biomarkers

P.R. Bushel*, F. Caiment, H. Wu, R. O'Lone, F. Day, J. Calley, A. Smith, J.Y. Li, A.H. Harrill

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

MicroRNAs (miRNAs) are small RNAs that regulate mRNA expression and have been targeted as biomarkers of organ damage and disease. To explore the utility of miRNAs to assess injury to specific tissues, a tissue atlas of miRNA abundance was constructed. The Rat Atlas of Tissue-specific and Enriched miRNAs (RATEmiRs) catalogues miRNA sequencing data from 21 and 23 tissues in male and female Sprague-Dawley rats, respectively. RATEmiRs identifies tissue-enriched (TE), tissue-specific (TS), or organ-specific (OS) miRNAs via comparisons of one or more tissue or organ vs others. We provide a brief overview of RATEmiRs and present how to use it to detect miRNA expression abundance of candidate biomarkers as well as to compare the expression of miRNAs between rat and human. The database is available at
Original languageEnglish
Pages (from-to)630-636
Number of pages7
JournalRna Biology
Volume17
Issue number5
DOIs
Publication statusPublished - 3 May 2020

Keywords

  • biomarker
  • genomics
  • identification
  • microrna
  • microrna biomarkers
  • mir-122
  • mirbase
  • mirna expression
  • organ-specific
  • plasma
  • ratemirs
  • rna-seq
  • tissue-enriched
  • tissue-specific
  • toxicity
  • miRNA expression
  • PLASMA
  • TOXICITY
  • IDENTIFICATION
  • MIR-122
  • GENOMICS
  • MIRBASE
  • RNA-Seq
  • MICRORNA BIOMARKERS
  • RATEmiRs
  • microRNA

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