@article{2a0c4eb28d894970bf8883995e681534,
title = "RATEmiRs: the rat atlas of tissue-specific and enriched miRNAs for discerning baseline expression exclusivity of candidate biomarkers",
abstract = "MicroRNAs (miRNAs) are small RNAs that regulate mRNA expression and have been targeted as biomarkers of organ damage and disease. To explore the utility of miRNAs to assess injury to specific tissues, a tissue atlas of miRNA abundance was constructed. The Rat Atlas of Tissue-specific and Enriched miRNAs (RATEmiRs) catalogues miRNA sequencing data from 21 and 23 tissues in male and female Sprague-Dawley rats, respectively. RATEmiRs identifies tissue-enriched (TE), tissue-specific (TS), or organ-specific (OS) miRNAs via comparisons of one or more tissue or organ vs others. We provide a brief overview of RATEmiRs and present how to use it to detect miRNA expression abundance of candidate biomarkers as well as to compare the expression of miRNAs between rat and human. The database is available at",
keywords = "biomarker, genomics, identification, microrna, microrna biomarkers, mir-122, mirbase, mirna expression, organ-specific, plasma, ratemirs, rna-seq, tissue-enriched, tissue-specific, toxicity, miRNA expression, PLASMA, TOXICITY, IDENTIFICATION, MIR-122, GENOMICS, MIRBASE, RNA-Seq, MICRORNA BIOMARKERS, RATEmiRs, microRNA",
author = "P.R. Bushel and F. Caiment and H. Wu and R. O'Lone and F. Day and J. Calley and A. Smith and J.Y. Li and A.H. Harrill",
note = "Funding Information: The rat atlas miRNA study was supported by Eli Lilly. The Health and Environmental Sciences Institute (HESI) scientific initiative is primarily supported by in-kind contributions (from public and private sector participants) of time, expertise, and experimental efforts. These contributions are supplemented by direct funding (that largely supports program infrastructure and management) that was provided by HESI?s corporate sponsors. A list of supporting organizations (public and private) is available at http://www.hesiglobal.org. The authors thank Drs. Scott Auerbach and Arun Pandiri for their comments to improve the manuscript. This research was supported, in part, by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS). The authors greatly appreciate the NIEHS Office of Scientific Computing and the NIEHS Computer Technology Branch for computational, web and application development resources to support RATEmiRs. Funding Information: The rat atlas miRNA study was supported by Eli Lilly. The Health and Environmental Sciences Institute (HESI) scientific initiative is primarily supported by in-kind contributions (from public and private sector participants) of time, expertise, and experimental efforts. These contributions are supplemented by direct funding (that largely supports program infrastructure and management) that was provided by HESI{\textquoteright}s corporate sponsors. A list of supporting organizations (public and private) is available at http://www.hesiglobal.org . The authors thank Drs. Scott Auerbach and Arun Pandiri for their comments to improve the manuscript. This research was supported, in part, by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS). The authors greatly appreciate the NIEHS Office of Scientific Computing and the NIEHS Computer Technology Branch for computational, web and application development resources to support RATEmiRs. Publisher Copyright: {\textcopyright} 2020, This work was authored as part of the Contributor{\textquoteright}s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.",
year = "2020",
month = may,
day = "3",
doi = "10.1080/15476286.2020.1724715",
language = "English",
volume = "17",
pages = "630--636",
journal = "Rna Biology",
issn = "1547-6286",
publisher = "Routledge/Taylor & Francis Group",
number = "5",
}