Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control

Hessel F. Groenveld; Jan G. P. Tijssen; Harry J. G. M. Crijns; Maarten P. Van den Berg; Hans L. Hillege; Marco Alings; Dirk J. Van Veldhuisen; Isabelle C. Van Gelder

doi:10.1016/j.jacc.2012.11.038

Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control

Hessel F. Groenveld, Jan G. P. Tijssen, Harry J. G. M. Crijns, Maarten P. Van den Berg, Hans L. Hillege, Marco Alings, Dirk J. Van Veldhuisen, Isabelle C. Van Gelder^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, in the strict group not all patients achieved the pre-defined heart rate target. Methods The primary outcome was a composite of cardiovascular morbidity and mortality. For the current analysis outcome events were analyzed from end of the dose-adjustment phase until end of follow-up (median 2.9 years [interquartile range: 2.4 to 3.0 years]). Of 614 patients, 608 completed the dose-adjustment phase-301 in the strict (resting heart rate

Original language	English
Pages (from-to)	741-748
Journal	Journal of the American College of Cardiology
Volume	61
Issue number	7
DOIs	https://doi.org/10.1016/j.jacc.2012.11.038
Publication status	Published - 19 Feb 2013

Keywords

atrial fibrillation
outcome
quality of life
rate control

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Groenveld, H. F., Tijssen, J. G. P., Crijns, H. J. G. M., Van den Berg, M. P., Hillege, H. L., Alings, M., Van Veldhuisen, D. J., & Van Gelder, I. C. (2013). Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control. Journal of the American College of Cardiology, 61(7), 741-748. https://doi.org/10.1016/j.jacc.2012.11.038

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title = "Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control",

abstract = "Objectives This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, in the strict group not all patients achieved the pre-defined heart rate target. Methods The primary outcome was a composite of cardiovascular morbidity and mortality. For the current analysis outcome events were analyzed from end of the dose-adjustment phase until end of follow-up (median 2.9 years [interquartile range: 2.4 to 3.0 years]). Of 614 patients, 608 completed the dose-adjustment phase-301 in the strict (resting heart rate ",

keywords = "atrial fibrillation, outcome, quality of life, rate control",

author = "Groenveld, {Hessel F.} and Tijssen, {Jan G. P.} and Crijns, {Harry J. G. M.} and {Van den Berg}, {Maarten P.} and Hillege, {Hans L.} and Marco Alings and {Van Veldhuisen}, {Dirk J.} and {Van Gelder}, {Isabelle C.}",

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doi = "10.1016/j.jacc.2012.11.038",

language = "English",

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journal = "Journal of the American College of Cardiology",

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Groenveld, HF, Tijssen, JGP, Crijns, HJGM, Van den Berg, MP, Hillege, HL, Alings, M, Van Veldhuisen, DJ & Van Gelder, IC 2013, 'Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control', Journal of the American College of Cardiology, vol. 61, no. 7, pp. 741-748. https://doi.org/10.1016/j.jacc.2012.11.038

Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control. / Groenveld, Hessel F.; Tijssen, Jan G. P.; Crijns, Harry J. G. M. et al.
In: Journal of the American College of Cardiology, Vol. 61, No. 7, 19.02.2013, p. 741-748.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control

AU - Groenveld, Hessel F.

AU - Tijssen, Jan G. P.

AU - Crijns, Harry J. G. M.

AU - Van den Berg, Maarten P.

AU - Hillege, Hans L.

AU - Alings, Marco

AU - Van Veldhuisen, Dirk J.

AU - Van Gelder, Isabelle C.

PY - 2013/2/19

Y1 - 2013/2/19

N2 - Objectives This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, in the strict group not all patients achieved the pre-defined heart rate target. Methods The primary outcome was a composite of cardiovascular morbidity and mortality. For the current analysis outcome events were analyzed from end of the dose-adjustment phase until end of follow-up (median 2.9 years [interquartile range: 2.4 to 3.0 years]). Of 614 patients, 608 completed the dose-adjustment phase-301 in the strict (resting heart rate

AB - Objectives This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, in the strict group not all patients achieved the pre-defined heart rate target. Methods The primary outcome was a composite of cardiovascular morbidity and mortality. For the current analysis outcome events were analyzed from end of the dose-adjustment phase until end of follow-up (median 2.9 years [interquartile range: 2.4 to 3.0 years]). Of 614 patients, 608 completed the dose-adjustment phase-301 in the strict (resting heart rate

KW - atrial fibrillation

KW - outcome

KW - quality of life

KW - rate control

U2 - 10.1016/j.jacc.2012.11.038

DO - 10.1016/j.jacc.2012.11.038

M3 - Article

C2 - 23410544

SN - 0735-1097

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SP - 741

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JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 7

ER -

Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control

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Keywords

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