Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control

Hessel F. Groenveld, Jan G. P. Tijssen, Harry J. G. M. Crijns, Maarten P. Van den Berg, Hans L. Hillege, Marco Alings, Dirk J. Van Veldhuisen, Isabelle C. Van Gelder*

*Corresponding author for this work

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Objectives This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, in the strict group not all patients achieved the pre-defined heart rate target. Methods The primary outcome was a composite of cardiovascular morbidity and mortality. For the current analysis outcome events were analyzed from end of the dose-adjustment phase until end of follow-up (median 2.9 years [interquartile range: 2.4 to 3.0 years]). Of 614 patients, 608 completed the dose-adjustment phase-301 in the strict (resting heart rate
Original languageEnglish
Pages (from-to)741-748
JournalJournal of the American College of Cardiology
Issue number7
Publication statusPublished - 19 Feb 2013


  • atrial fibrillation
  • outcome
  • quality of life
  • rate control

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