Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin

Leo H. J. Jacobs; Marcel van Borren; Eugenie Gemen; Martijn van Eck; Bas van Son; Jan F. C. Glatz; Marcel Daniels; Ron Kusters

doi:10.1177/0004563215578189

Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin

Leo H. J. Jacobs, Marcel van Borren, Eugenie Gemen, Martijn van Eck, Bas van Son, Jan F. C. Glatz, Marcel Daniels, Ron Kusters^*

^*Corresponding author for this work

G&C - Moleculaire Genetica

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of acute myocardial infarction could improve the early diagnostic assessment of patients presenting with chest pain. Methods We measured cardiac troponin I, copeptin and heart-type fatty acid-binding protein concentrations in 584 patients who presented to the emergency department with acute chest pain. The diagnostic performances for the diagnosis of acute myocardial infarction and NSTEMI were calculated for the individual markers and their combinations. Separate calculations were made for patients presenting to the emergency department

Original language	English
Pages (from-to)	550-561
Journal	Annals of Clinical Biochemistry
Volume	52
Issue number	5
DOIs	https://doi.org/10.1177/0004563215578189
Publication status	Published - Sep 2015

Keywords

Acute myocardial infarction
copeptin
heart-type fatty acid-binding protein
troponin

Access to Document

10.1177/0004563215578189

Full TextFinal published version, 445 KBLicence: Taverne

Cite this

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title = "Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin",

abstract = "Background The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of acute myocardial infarction could improve the early diagnostic assessment of patients presenting with chest pain. Methods We measured cardiac troponin I, copeptin and heart-type fatty acid-binding protein concentrations in 584 patients who presented to the emergency department with acute chest pain. The diagnostic performances for the diagnosis of acute myocardial infarction and NSTEMI were calculated for the individual markers and their combinations. Separate calculations were made for patients presenting to the emergency department ",

keywords = "Acute myocardial infarction, copeptin, heart-type fatty acid-binding protein, troponin",

author = "Jacobs, {Leo H. J.} and {van Borren}, Marcel and Eugenie Gemen and {van Eck}, Martijn and {van Son}, Bas and Glatz, {Jan F. C.} and Marcel Daniels and Ron Kusters",

year = "2015",

month = sep,

doi = "10.1177/0004563215578189",

language = "English",

volume = "52",

pages = "550--561",

journal = "Annals of Clinical Biochemistry",

issn = "0004-5632",

publisher = "SAGE Publications Inc.",

number = "5",

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TY - JOUR

T1 - Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin

AU - Jacobs, Leo H. J.

AU - van Borren, Marcel

AU - Gemen, Eugenie

AU - van Eck, Martijn

AU - van Son, Bas

AU - Glatz, Jan F. C.

AU - Daniels, Marcel

AU - Kusters, Ron

PY - 2015/9

Y1 - 2015/9

N2 - Background The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of acute myocardial infarction could improve the early diagnostic assessment of patients presenting with chest pain. Methods We measured cardiac troponin I, copeptin and heart-type fatty acid-binding protein concentrations in 584 patients who presented to the emergency department with acute chest pain. The diagnostic performances for the diagnosis of acute myocardial infarction and NSTEMI were calculated for the individual markers and their combinations. Separate calculations were made for patients presenting to the emergency department

AB - Background The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of acute myocardial infarction could improve the early diagnostic assessment of patients presenting with chest pain. Methods We measured cardiac troponin I, copeptin and heart-type fatty acid-binding protein concentrations in 584 patients who presented to the emergency department with acute chest pain. The diagnostic performances for the diagnosis of acute myocardial infarction and NSTEMI were calculated for the individual markers and their combinations. Separate calculations were made for patients presenting to the emergency department

KW - Acute myocardial infarction

KW - copeptin

KW - heart-type fatty acid-binding protein

KW - troponin

U2 - 10.1177/0004563215578189

DO - 10.1177/0004563215578189

M3 - Article

C2 - 25732130

VL - 52

SP - 550

EP - 561

JO - Annals of Clinical Biochemistry

JF - Annals of Clinical Biochemistry

SN - 0004-5632

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