Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin

Leo H. J. Jacobs, Marcel van Borren, Eugenie Gemen, Martijn van Eck, Bas van Son, Jan F. C. Glatz, Marcel Daniels, Ron Kusters*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of acute myocardial infarction could improve the early diagnostic assessment of patients presenting with chest pain. Methods We measured cardiac troponin I, copeptin and heart-type fatty acid-binding protein concentrations in 584 patients who presented to the emergency department with acute chest pain. The diagnostic performances for the diagnosis of acute myocardial infarction and NSTEMI were calculated for the individual markers and their combinations. Separate calculations were made for patients presenting to the emergency department
Original languageEnglish
Pages (from-to)550-561
JournalAnnals of Clinical Biochemistry
Issue number5
Publication statusPublished - Sep 2015


  • Acute myocardial infarction
  • copeptin
  • heart-type fatty acid-binding protein
  • troponin

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