Randomised comparison of drugeluting versus bare-metal stenting in patients with non-ST elevation myocardial infarction

Wouter S. Remkes, Erik A. Badings, R.S. Hermanides, Saman Rasoul, Jan-Henk E. Dambrink, Petra C. Koopmans, Salem H.K. The, Jan Paul Ottervanger, A.T. Marcel Gosselink, Jan Hoorntje, Harry Suryapranata, Arnoud W.J. van 't Hof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: The superiority of drug-eluting stents (DES) over bare-metal stents (BMS) in patients with ST elevation myocardial infarction (STEMI) is well studied; however, randomised data in patients with non-ST elevation myocardial infarction (NSTEMI) are lacking. The objective of this study was to investigate whether stenting with everolimus-eluting stents (EES) safely reduces restenosis in patients with NSTEMI as compared to BMS.

Methods: ELISA-3 patients were asked to participate in the angiographic substudy and were randomised to DE (Xience V) or BM (Vision) stenting (ELISA-3 group). The primary end point was minimal luminal diameter (MLD) at 9-month follow-up angiography. In addition, 296 patients with NSTEMI who were excluded or did not want to participate in the ELISA-3 trial (RELI group) were randomised to DE or BM stenting and underwent clinical follow-up only (major adverse cardiac events (MACE), stent thrombosis (ST)). A pooled analysis was performed to assess an effect on clinical outcome.

Results: 178 of 540 ELISA-3 patients participated in the angiographic substudy. MLD at 9 months angiography was 2.37 +/- 0.63 mm (DES) versus 1.84 +/- 0.62 mm (BMS), p

Conclusions: In patients with NSTEMI, use of EES is safe and decreases both angiographic and clinical restenosis as compared to BMS http://www.isrctn.com/search?q=39230163.

Original languageEnglish
Article numbere000455
Number of pages8
JournalOpen Heart
Volume3
Issue number2
DOIs
Publication statusPublished - Aug 2016

Keywords

  • BALLOON ANGIOPLASTY
  • UNCOATED STENTS
  • CORONARY
  • OUTCOMES
  • THROMBOGENICITY
  • INTERVENTION
  • METAANALYSIS
  • RESTENOSIS
  • SEGMENT
  • TRIALS

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