Radiotherapy and immunotherapy: the perfect partnership

Nicolle Hubertine Rekers

Research output: ThesisDoctoral ThesisExternal prepared

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Abstract

The overall goal of this dissertation was to examine the systemic anti-tumour effects of irradiation in combination with immunotherapy (L19-IL2). Recently, it has been shown that tumour irradiation initiates an immune reaction and L19-IL2 has the potential to strengthen this anti-tumour immune response targeted at the tumour. In this dissertation, we show that irradiation plus L19-IL2 results in a strong immune response against the tumour with long-lasting healing in certain tumour models. The generated immune response has the same effects on tumours outside the irradiated area and can prevent new tumour formation. These results have led to a Phase I clinical trial.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Lambin, Philippe, Supervisor
  • Dubois, Ludwig, Advisor
  • Yaromina, Ala, Advisor
Award date9 Mar 2017
Place of PublicationMaastricht
Publisher
Print ISBNs9789461596710
DOIs
Publication statusPublished - 2017

Keywords

  • immunotherapy
  • irradiation
  • translational research
  • abscopal effect

Cite this

Rekers, N. H. (2017). Radiotherapy and immunotherapy: the perfect partnership. Datawyse / Universitaire Pers Maastricht. https://doi.org/10.26481/dis.20170309nr