Radiotherapy and immunotherapy: the perfect partnership

Nicolle Hubertine Rekers

doi:10.26481/dis.20170309nr

Radiotherapy and immunotherapy: the perfect partnership

Nicolle Hubertine Rekers

Research output: Thesis › Doctoral Thesis › External prepared

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Abstract

The overall goal of this dissertation was to examine the systemic anti-tumour effects of irradiation in combination with immunotherapy (L19-IL2). Recently, it has been shown that tumour irradiation initiates an immune reaction and L19-IL2 has the potential to strengthen this anti-tumour immune response targeted at the tumour. In this dissertation, we show that irradiation plus L19-IL2 results in a strong immune response against the tumour with long-lasting healing in certain tumour models. The generated immune response has the same effects on tumours outside the irradiated area and can prevent new tumour formation. These results have led to a Phase I clinical trial.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Lambin, Philippe, Supervisor Dubois, Ludwig, Co-Supervisor Yaromina, Ala, Co-Supervisor
Award date	9 Mar 2017
Place of Publication	Maastricht
Publisher	Datawyse / Universitaire Pers Maastricht
Print ISBNs	9789461596710
DOIs	https://doi.org/10.26481/dis.20170309nr
Publication status	Published - 2017

Keywords

immunotherapy
irradiation
translational research
abscopal effect

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Cite this

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title = "Radiotherapy and immunotherapy: the perfect partnership",

abstract = "The overall goal of this dissertation was to examine the systemic anti-tumour effects of irradiation in combination with immunotherapy (L19-IL2). Recently, it has been shown that tumour irradiation initiates an immune reaction and L19-IL2 has the potential to strengthen this anti-tumour immune response targeted at the tumour. In this dissertation, we show that irradiation plus L19-IL2 results in a strong immune response against the tumour with long-lasting healing in certain tumour models. The generated immune response has the same effects on tumours outside the irradiated area and can prevent new tumour formation. These results have led to a Phase I clinical trial.",

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AB - The overall goal of this dissertation was to examine the systemic anti-tumour effects of irradiation in combination with immunotherapy (L19-IL2). Recently, it has been shown that tumour irradiation initiates an immune reaction and L19-IL2 has the potential to strengthen this anti-tumour immune response targeted at the tumour. In this dissertation, we show that irradiation plus L19-IL2 results in a strong immune response against the tumour with long-lasting healing in certain tumour models. The generated immune response has the same effects on tumours outside the irradiated area and can prevent new tumour formation. These results have led to a Phase I clinical trial.

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Radiotherapy and immunotherapy: the perfect partnership

Abstract

Keywords

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