Radiomics applied to lung cancer: a review

Madeleine Scrivener*, Evelyn E. C. de Jong, Janita van Timmeren, Thierry Pieters, Benoit Ghaye, Xavier Geets

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Lung cancers exhibit strong phenotypic differences that can be visualized noninvasively by medical imaging. Radiomics, a concept introduced in 2012, refers to the comprehensive quantification of tumor phenotypes by applying a large number of quantitative image features (watch the animation: and the website Here, we review the literature related to radiomics for lung cancer. We found 11 papers related to computed tomography (CT) radiomics, 3 to radiomics or texture analysis with positron emission tomography (PET) and 8 relating to PET/CT radiomics. There are two main applications of radiomics, the classification of lung nodules (diagnostic) or prognostication of established lung cancer (theragnostic). There are quite a few methodological issues in most of the reviewed papers. Only 5 studies, out of the 22, were externally validated. Overall, it is clear that radiomics offers great potential in improving diagnosis and patient stratification in lung cancer. It may also have a real clinical impact, as imaging is routinely used in clinical practice, providing an unprecedented opportunity to improve decision support in lung cancer treatment at low cost.
Original languageEnglish
Pages (from-to)398-409
JournalTranslational Cancer Research
Issue number4
Publication statusPublished - Aug 2016


  • Lung cancer
  • imaging
  • radiomics
  • theragnostic

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