Radiological changes with magnetic resonance imaging and computed tomography after irradiating minipig mandibles: The role of T2-SPIR mixed signal intensities in the detection of osteoradionecrosis

Lucas J. Poort*, Alida A. Postma, Annika A. R. Stadler, Roland A. Bockmann, Frank J. Hoebers, Peter A. W. H. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Purpose: Radiotherapy in the head and neck can induce several radiologically detectable changes in bone, osteoradionecrosis (ORN) among them. The purpose is to investigate radiological changes in mandibular bone after irradiation with various doses with and without surgery and to determine imaging characteristics of radiotherapy and ORN in an animal model.

Materials and methods: Sixteen Gottingen minipigs were divided into groups and were irradiated with two fractions with equivalent doses of 0, 25, 50 and 70 Gray. Thirteen weeks after irradiation, left mandibular teeth were removed and dental implants were placed. CT-scans and MR-imaging were made before irradiation and twenty-six weeks after. Alterations in the bony structures were recorded on CT-scan and MR-imaging and scored by two head-neck radiologists.

Results: Increased signal changes on MR-imaging were associated with higher radiation doses. Two animals developed ORN clinically. Radiologically mixed signal intensities on T2-SPIR were seen. On CT-scans cortical destruction was found in three animals. Based on imaging, three animals were diagnosed with ORN.

Conclusion: Irradiation of minipig mandibles with various doses induced damages of the mandibular bone. Imaging with CT-scan and MR-imaging showed signal and structural changes that can be interpreted as prolonged and insufficient repair of radiation induced bone damages. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalJournal of Cranio-Maxillofacial Surgery
Volume45
Issue number5
DOIs
Publication statusPublished - May 2017

Keywords

  • Irradiation
  • Radiological changes
  • Mandible
  • Osteoradionecrosis
  • Animal experiment
  • MANDIBULAR OSTEORADIONECROSIS
  • NECK-CANCER
  • GOTTINGEN MINIPIGS
  • RADIATION-THERAPY
  • CT FINDINGS
  • BONE
  • HEAD
  • RADIOTHERAPY
  • MR
  • PATHOPHYSIOLOGY

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