Abstract
N,N'-bis(diethylenetriamine pentaacetic acid)-3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) (bis-DTPA-BI) was radiolabeled with (99m)Tc(CO)(3). The resulting (99m)Tc(CO)(3)-bis-DTPA-BI was characterized (LC-MS) and evaluated as a potential SPECT tracer for imaging of necrosis in Wistar rats with a reperfused partial liver infarction and Wistar rats with ethanol induced muscular necrosis. To study the specificity, uptake of (99m)Tc(CO)(3)-bis-DTPA-BI was also studied in a mouse model of Fas-mediated hepatic apoptosis. The obtained results indicate that (99m)Tc(CO)(3)-bis-DTPA-BI displays selective uptake in necrotic tissue and can be used for in vivo visualization of necrosis by SPECT.
Original language | English |
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Pages (from-to) | 502-505 |
Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 21 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2011 |
Keywords
- Cell death
- Necrosis
- Tc-99m(CO)(3)
- SPECT
- Benzylidene-bis-indole