An efficient and simple synthesis approach to form stable (68) Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 +/- 50 nm. The radionuclide (68) Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these (68) Ga-nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.
- poly(ethylene glycol)
- positron emission tomography
Singh, S., Bingol, B., Morgenroth, A., Mottaghy, F. M., Moller, M., & Schmaljohann, J. (2013). Radiolabeled nanogels for nuclear molecular imaging. Macromolecular Rapid Communications, 34(7), 562-567. https://doi.org/10.1002/marc.201200744