Radiolabeled nanogels for nuclear molecular imaging

S. Singh, B. Bingol, A. Morgenroth, F.M. Mottaghy, M. Moller, J. Schmaljohann

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

An efficient and simple synthesis approach to form stable (68) Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 +/- 50 nm. The radionuclide (68) Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these (68) Ga-nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.
Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalMacromolecular Rapid Communications
Volume34
Issue number7
DOIs
Publication statusPublished - 12 Apr 2013

Keywords

  • Gallium-68
  • nanogels
  • poly(ethylene glycol)
  • positron emission tomography
  • self-assembly
  • IN-VIVO
  • DELIVERY
  • COPOLYMERS
  • BIODISTRIBUTION
  • THERAPEUTICS
  • PET

Cite this

Singh, S., Bingol, B., Morgenroth, A., Mottaghy, F. M., Moller, M., & Schmaljohann, J. (2013). Radiolabeled nanogels for nuclear molecular imaging. Macromolecular Rapid Communications, 34(7), 562-567. https://doi.org/10.1002/marc.201200744