Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review

Lukas Kaesmann; Alexander Dietrich; Claudia A. Staab-Weijnitz; Farkhad Manapov; Juergen Behr; Andreas Rimner; Branislav Jeremic; Suresh Senan; Dirk De Ruysscher; Kirsten Lauber; Claus Belka

doi:10.1186/s13014-020-01654-9

Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review

Lukas Kaesmann^*, Alexander Dietrich, Claudia A. Staab-Weijnitz, Farkhad Manapov, Juergen Behr, Andreas Rimner, Branislav Jeremic, Suresh Senan, Dirk De Ruysscher, Kirsten Lauber, Claus Belka

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

Original language	English
Article number	214
Number of pages	16
Journal	Radiation Oncology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s13014-020-01654-9
Publication status	Published - 10 Sept 2020

Keywords

BREAST-CANCER PATIENTS
CLINICAL-FEATURES
CONCURRENT CHEMOTHERAPY
EUROPEAN-ORGANIZATION
HYPERFRACTIONATED RADIATION
OBLITERANS ORGANIZING PNEUMONIA
RISK-FACTORS
STEM-CELLS
THORACIC RADIOTHERAPY
TUMOR VOLUME

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title = "Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review",

abstract = "Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.",

keywords = "BREAST-CANCER PATIENTS, CLINICAL-FEATURES, CONCURRENT CHEMOTHERAPY, EUROPEAN-ORGANIZATION, HYPERFRACTIONATED RADIATION, OBLITERANS ORGANIZING PNEUMONIA, RISK-FACTORS, STEM-CELLS, THORACIC RADIOTHERAPY, TUMOR VOLUME",

author = "Lukas Kaesmann and Alexander Dietrich and Staab-Weijnitz, {Claudia A.} and Farkhad Manapov and Juergen Behr and Andreas Rimner and Branislav Jeremic and Suresh Senan and {De Ruysscher}, Dirk and Kirsten Lauber and Claus Belka",

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year = "2020",

month = sep,

day = "10",

doi = "10.1186/s13014-020-01654-9",

language = "English",

volume = "15",

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T1 - Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review

AU - Kaesmann, Lukas

AU - Dietrich, Alexander

AU - Staab-Weijnitz, Claudia A.

AU - Manapov, Farkhad

AU - Behr, Juergen

AU - Rimner, Andreas

AU - Jeremic, Branislav

AU - Senan, Suresh

AU - De Ruysscher, Dirk

AU - Lauber, Kirsten

AU - Belka, Claus

PY - 2020/9/10

Y1 - 2020/9/10

N2 - Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

AB - Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

KW - BREAST-CANCER PATIENTS

KW - CLINICAL-FEATURES

KW - CONCURRENT CHEMOTHERAPY

KW - EUROPEAN-ORGANIZATION

KW - HYPERFRACTIONATED RADIATION

KW - OBLITERANS ORGANIZING PNEUMONIA

KW - RISK-FACTORS

KW - STEM-CELLS

KW - THORACIC RADIOTHERAPY

KW - TUMOR VOLUME

U2 - 10.1186/s13014-020-01654-9

DO - 10.1186/s13014-020-01654-9

M3 - (Systematic) Review article

C2 - 32912295

SN - 1748-717X

VL - 15

JO - Radiation Oncology

JF - Radiation Oncology

IS - 1

M1 - 214

ER -

Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review

Abstract

Keywords

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