Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review

Lukas Kaesmann*, Alexander Dietrich, Claudia A. Staab-Weijnitz, Farkhad Manapov, Juergen Behr, Andreas Rimner, Branislav Jeremic, Suresh Senan, Dirk De Ruysscher, Kirsten Lauber, Claus Belka

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Citations (Web of Science)

Abstract

Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

Original languageEnglish
Article number214
Number of pages16
JournalRadiation Oncology
Volume15
Issue number1
DOIs
Publication statusPublished - 10 Sep 2020

Keywords

  • OBLITERANS ORGANIZING PNEUMONIA
  • BREAST-CANCER PATIENTS
  • HYPERFRACTIONATED RADIATION
  • CONCURRENT CHEMOTHERAPY
  • THORACIC RADIOTHERAPY
  • EUROPEAN-ORGANIZATION
  • CLINICAL-FEATURES
  • TUMOR VOLUME
  • RISK-FACTORS
  • STEM-CELLS

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