TY - JOUR
T1 - Radiation dose constraints for organs at risk in neuro-oncology
T2 - the European Particle Therapy Network consensus
AU - Lambrecht, Maarten
AU - Eekers, Danielle B. P.
AU - Alapetite, Claire
AU - Burnet, Neil G.
AU - Calugaru, Valentin
AU - Coremans, Ida E. M.
AU - Fossati, Piero
AU - Hoyer, Morten
AU - Langendijk, Johannes A.
AU - Romero, Alejandra Mendez
AU - Paulsen, Frank
AU - Perpar, Ana
AU - Renard, Laurette
AU - de Ruysscher, Dirk
AU - Timmermann, Beate
AU - Vitek, Pavel
AU - Weber, Damien C.
AU - van der Weide, Hiske L.
AU - Whitfield, Gillian A.
AU - Wiggenraad, Ruud
AU - Roelofs, Erik
AU - Nystrom, Petra Witt
AU - Troost, Esther G. C.
AU - Taskforce European Particle
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Purpose: For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study. Methods: We performed a comprehensive search to identify the current papers on OAR dose constraints for normofractionated photon and particle therapy in PubMed, Ovid Medline, Cochrane Library, Embase and Web of Science. Moreover, the included articles' reference lists were cross-checked for potential studies that met the inclusion criteria. Consensus was reached among 20 radiation oncology experts in the field of neuro-oncology. Results: For the OARs published in the neuro-oncology literature, we summarized the available literature and recommended dose constraints associated with certain levels of normal tissue complication probability (NTCP) according to the recent ICRU recommendations. For those OARs with lacking or insufficient NTCP data, a proposal for effective and efficient data collection is given. Conclusion: The use of the European Particle Therapy Network-consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities. (C) 2018 Elsevier B.V. All rights reserved.
AB - Purpose: For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study. Methods: We performed a comprehensive search to identify the current papers on OAR dose constraints for normofractionated photon and particle therapy in PubMed, Ovid Medline, Cochrane Library, Embase and Web of Science. Moreover, the included articles' reference lists were cross-checked for potential studies that met the inclusion criteria. Consensus was reached among 20 radiation oncology experts in the field of neuro-oncology. Results: For the OARs published in the neuro-oncology literature, we summarized the available literature and recommended dose constraints associated with certain levels of normal tissue complication probability (NTCP) according to the recent ICRU recommendations. For those OARs with lacking or insufficient NTCP data, a proposal for effective and efficient data collection is given. Conclusion: The use of the European Particle Therapy Network-consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities. (C) 2018 Elsevier B.V. All rights reserved.
KW - Dose constraints
KW - Organs at risk
KW - Particle therapy
KW - European Particle Therapy Network
KW - INTENSITY-MODULATED RADIOTHERAPY
KW - EXTERNAL-BEAM IRRADIATION
KW - SENSORINEURAL HEARING-LOSS
KW - INDUCED OPTIC NEUROPATHY
KW - NONPITUITARY BRAIN-TUMORS
KW - MODEL-BASED APPROACH
KW - SKULL BASE TUMORS
KW - DRY-EYE SYNDROME
KW - TERM-FOLLOW-UP
KW - NASOPHARYNGEAL CARCINOMA
U2 - 10.1016/j.radonc.2018.05.001
DO - 10.1016/j.radonc.2018.05.001
M3 - (Systematic) Review article
C2 - 29779919
SN - 0167-8140
VL - 128
SP - 26
EP - 36
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 1
ER -