Radial gradient and radial deviation radiomic features from pre-surgical CT scans are associated with survival among lung adenocarcinoma patients

Ilke Tunali, Olya Stringfield, Albert Guvenis, Hua Wang, Ying Liu, Yoganand Balagurunathan, Philippe Lambin, Robert J. Gillies, Matthew B. Schabath*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)

Abstract

The goal of this study was to extract features from radial deviation and radial gradient maps which were derived from thoracic CT scans of patients diagnosed with lung adenocarcinoma and assess whether these features are associated with overall survival. We used two independent cohorts from different institutions for training (n= 61) and test (n= 47) and focused our analyses on features that were non-redundant and highly reproducible. To reduce the number of features and covariates into a single parsimonious model, a backward elimination approach was applied. Out of 48 features that were extracted, 31 were eliminated because they were not reproducible or were redundant. We considered 17 features for statistical analysis and identified a final model containing the two most highly informative features that were associated with lung cancer survival. One of the two features, radial deviation outside-border separation standard deviation, was replicated in a test cohort exhibiting a statistically significant association with lung cancer survival (multivariable hazard ratio = 0.40; 95% confidence interval 0.17-0.97). Additionally, we explored the biological underpinnings of these features and found radial gradient and radial deviation image features were significantly associated with semantic radiological features.

Original languageEnglish
Pages (from-to)96013-96026
Number of pages14
JournalOncotarget
Volume8
Issue number56
DOIs
Publication statusPublished - 10 Nov 2017

Keywords

  • radiomics
  • radial gradient
  • radial deviation
  • lung adenocarcinoma
  • quantitative imaging
  • GROWTH-FACTOR RECEPTOR
  • PROGNOSTIC-FACTORS
  • PULMONARY NODULES
  • CANCER PATIENTS
  • CELL
  • MUTATIONS
  • SEGMENTATION
  • EXPRESSION
  • TRENDS
  • IMAGES

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