Abstract
To review the literature about the use of Rabies Virus-Vaccine (RV-V) as an anticancer immunotherapeutic modality in the light of recent findings. The literature search in relevant databases with the following key words: Rabies virus, cancer, remission. Remissions occured following RV-V injections in patients with cervical cancer and melanoma. Pilot clinical studies showed that RV-V injections enhanced survival in glioblastoma patients, which is supported by findings in GL261 mouse glioma model. If public health studies demonstrate protective role of RV-V against certain types of cancers, it can be benefitted as a novel immune adjuvant in clinic.
| Original language | English |
|---|---|
| Pages (from-to) | 785-792 |
| Number of pages | 8 |
| Journal | Clinical & Translational Oncology |
| Volume | 19 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2017 |
Keywords
- Rabies virus
- Cancer
- Spontaneous remission
- Immunotherapy
- NERVOUS-SYSTEM
- GLYCOPROTEIN
- CLEARANCE
- DELIVERY
- RECEPTOR
- THERAPY
- SIRNA
- RVG
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