QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design

L.J.M.E. van der Does; A. Yaksh; C. Kik; P. Knops; E.A.H. Lanters; C.P. Teuwen; F.B.S. Oei; P.C. van de Woestijne; J.A. Bekkers; A.J.J.C. Bogers; M.A. Allessie; N.M.S. de Groot

doi:10.1007/s12265-016-9685-1

QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design

L.J.M.E. van der Does, A. Yaksh, C. Kik, P. Knops, E.A.H. Lanters, C.P. Teuwen, F.B.S. Oei, P.C. van de Woestijne, J.A. Bekkers, A.J.J.C. Bogers, M.A. Allessie, N.M.S. de Groot^*

^*Corresponding author for this work

Fysiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence of different pathophysiological processes. Individualized diagnosis and therapy of the arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims to identify the arrhythmogenic areas underlying AF by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with different heart diseases. Participants are divided into 12 groups according to the underlying heart diseases and presence of prior AF episodes. Mapping is performed with a 192-electrode array for 510 s during sinus rhythm and (induced) AF of the entire atrial surface. Local activation times are converted into activation and wave maps from which various electrophysiological parameters are derived. Postoperative cardiac rhythm registrations and a 5-year follow-up will show the incidence of postoperative and persistent AF. This project provides the first step in the development of a tool for individual AF diagnosis and treatment.

Original language	English
Pages (from-to)	194-201
Number of pages	8
Journal	Journal of Cardiovascular Translational Research
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s12265-016-9685-1
Publication status	Published - 1 Jun 2016

Keywords

Atrial fibrillation
Epicardial mapping
Electrophysiology
Cardiac surgery
Study design
CATHETER ABLATION
FOCAL IMPULSE
CYCLE LENGTH
ACTIVATION
CONDUCTION
MECHANISM
HEART

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van der Does, L. J. M. E., Yaksh, A., Kik, C., Knops, P., Lanters, E. A. H., Teuwen, C. P., Oei, F. B. S., van de Woestijne, P. C., Bekkers, J. A., Bogers, A. J. J. C., Allessie, M. A., & de Groot, N. M. S. (2016). QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design. Journal of Cardiovascular Translational Research, 9(3), 194-201. https://doi.org/10.1007/s12265-016-9685-1

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abstract = "The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence of different pathophysiological processes. Individualized diagnosis and therapy of the arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims to identify the arrhythmogenic areas underlying AF by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with different heart diseases. Participants are divided into 12 groups according to the underlying heart diseases and presence of prior AF episodes. Mapping is performed with a 192-electrode array for 510 s during sinus rhythm and (induced) AF of the entire atrial surface. Local activation times are converted into activation and wave maps from which various electrophysiological parameters are derived. Postoperative cardiac rhythm registrations and a 5-year follow-up will show the incidence of postoperative and persistent AF. This project provides the first step in the development of a tool for individual AF diagnosis and treatment.",

keywords = "Atrial fibrillation, Epicardial mapping, Electrophysiology, Cardiac surgery, Study design, CATHETER ABLATION, FOCAL IMPULSE, CYCLE LENGTH, ACTIVATION, CONDUCTION, MECHANISM, HEART",

author = "{van der Does}, L.J.M.E. and A. Yaksh and C. Kik and P. Knops and E.A.H. Lanters and C.P. Teuwen and F.B.S. Oei and {van de Woestijne}, P.C. and J.A. Bekkers and A.J.J.C. Bogers and M.A. Allessie and {de Groot}, N.M.S.",

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doi = "10.1007/s12265-016-9685-1",

language = "English",

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van der Does, LJME, Yaksh, A, Kik, C, Knops, P, Lanters, EAH, Teuwen, CP, Oei, FBS, van de Woestijne, PC, Bekkers, JA, Bogers, AJJC, Allessie, MA & de Groot, NMS 2016, 'QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design', Journal of Cardiovascular Translational Research, vol. 9, no. 3, pp. 194-201. https://doi.org/10.1007/s12265-016-9685-1

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AU - van der Does, L.J.M.E.

AU - Yaksh, A.

AU - Kik, C.

AU - Knops, P.

AU - Lanters, E.A.H.

AU - Teuwen, C.P.

AU - Oei, F.B.S.

AU - van de Woestijne, P.C.

AU - Bekkers, J.A.

AU - Bogers, A.J.J.C.

AU - Allessie, M.A.

AU - de Groot, N.M.S.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence of different pathophysiological processes. Individualized diagnosis and therapy of the arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims to identify the arrhythmogenic areas underlying AF by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with different heart diseases. Participants are divided into 12 groups according to the underlying heart diseases and presence of prior AF episodes. Mapping is performed with a 192-electrode array for 510 s during sinus rhythm and (induced) AF of the entire atrial surface. Local activation times are converted into activation and wave maps from which various electrophysiological parameters are derived. Postoperative cardiac rhythm registrations and a 5-year follow-up will show the incidence of postoperative and persistent AF. This project provides the first step in the development of a tool for individual AF diagnosis and treatment.

AB - The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence of different pathophysiological processes. Individualized diagnosis and therapy of the arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims to identify the arrhythmogenic areas underlying AF by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with different heart diseases. Participants are divided into 12 groups according to the underlying heart diseases and presence of prior AF episodes. Mapping is performed with a 192-electrode array for 510 s during sinus rhythm and (induced) AF of the entire atrial surface. Local activation times are converted into activation and wave maps from which various electrophysiological parameters are derived. Postoperative cardiac rhythm registrations and a 5-year follow-up will show the incidence of postoperative and persistent AF. This project provides the first step in the development of a tool for individual AF diagnosis and treatment.

KW - Atrial fibrillation

KW - Epicardial mapping

KW - Electrophysiology

KW - Cardiac surgery

KW - Study design

KW - CATHETER ABLATION

KW - FOCAL IMPULSE

KW - CYCLE LENGTH

KW - ACTIVATION

KW - CONDUCTION

KW - MECHANISM

KW - HEART

U2 - 10.1007/s12265-016-9685-1

DO - 10.1007/s12265-016-9685-1

M3 - Article

SN - 1937-5387

VL - 9

SP - 194

EP - 201

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 3

ER -

QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design

Abstract

Keywords

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