Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease

Thomas K. van der Made, Michele Fedecostante, Daniel Scotcher, Amin Rostami-Hodjegan, Javier Sastre Torano, Igor Middel, Andries S. Koster, Karin G. Gerritsen, Vera Jankowski, Joachim Jankowski, Joost G. J. Hoenderop, Rosalinde Masereeuw, Aleksandra Galetin

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)4551-4562
Number of pages12
JournalMolecular Pharmaceutics
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 2019

Keywords

  • indoxyl sulfate
  • OAT1
  • proximal tubule
  • in vitro-in vivo extrapolation
  • CKD
  • ORGANIC ANION TRANSPORTERS
  • DRUG-DRUG INTERACTIONS
  • P-CRESOL SULFATE
  • II-THE-BRAIN
  • RENAL CLEARANCE
  • UREMIC TOXINS
  • EFFLUX TRANSPORTERS
  • PLASMA-LEVELS
  • PROTEIN
  • PREDICTION

Cite this

van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A., Torano, J. S., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R., & Galetin, A. (2019). Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Molecular Pharmaceutics, 16(11), 4551-4562. https://doi.org/10.1021/acs.molpharmaceut.9b00681