Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease

Thomas K. van der Made; Michele Fedecostante; Daniel Scotcher; Amin Rostami-Hodjegan; Javier Sastre Torano; Igor Middel; Andries S. Koster; Karin G. Gerritsen; Vera Jankowski; Joachim Jankowski; Joost G. J. Hoenderop; Rosalinde Masereeuw; Aleksandra Galetin

doi:10.1021/acs.molpharmaceut.9b00681

Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease

Thomas K. van der Made, Michele Fedecostante, Daniel Scotcher, Amin Rostami-Hodjegan, Javier Sastre Torano, Igor Middel, Andries S. Koster, Karin G. Gerritsen, Vera Jankowski, Joachim Jankowski, Joost G. J. Hoenderop, Rosalinde Masereeuw^*, Aleksandra Galetin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	4551-4562
Number of pages	12
Journal	Molecular Pharmaceutics
Volume	16
Issue number	11
DOIs	https://doi.org/10.1021/acs.molpharmaceut.9b00681
Publication status	Published - Nov 2019

Keywords

indoxyl sulfate
OAT1
proximal tubule
in vitro-in vivo extrapolation
CKD
ORGANIC ANION TRANSPORTERS
DRUG-DRUG INTERACTIONS
P-CRESOL SULFATE
II-THE-BRAIN
RENAL CLEARANCE
UREMIC TOXINS
EFFLUX TRANSPORTERS
PLASMA-LEVELS
PROTEIN
PREDICTION

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10.1021/acs.molpharmaceut.9b00681

Cite this

van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A., Torano, J. S., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R., & Galetin, A. (2019). Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Molecular Pharmaceutics, 16(11), 4551-4562. https://doi.org/10.1021/acs.molpharmaceut.9b00681

van der Made, Thomas K. ; Fedecostante, Michele ; Scotcher, Daniel ; Rostami-Hodjegan, Amin ; Torano, Javier Sastre ; Middel, Igor ; Koster, Andries S. ; Gerritsen, Karin G. ; Jankowski, Vera ; Jankowski, Joachim ; Hoenderop, Joost G. J. ; Masereeuw, Rosalinde ; Galetin, Aleksandra. / Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. In: Molecular Pharmaceutics. 2019 ; Vol. 16, No. 11. pp. 4551-4562.

@article{5eb8e3450dc34417bc149909ab34cea7,

title = "Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease",

keywords = "indoxyl sulfate, OAT1, proximal tubule, in vitro-in vivo extrapolation, CKD, ORGANIC ANION TRANSPORTERS, DRUG-DRUG INTERACTIONS, P-CRESOL SULFATE, II-THE-BRAIN, RENAL CLEARANCE, UREMIC TOXINS, EFFLUX TRANSPORTERS, PLASMA-LEVELS, PROTEIN, PREDICTION",

author = "{van der Made}, {Thomas K.} and Michele Fedecostante and Daniel Scotcher and Amin Rostami-Hodjegan and Torano, {Javier Sastre} and Igor Middel and Koster, {Andries S.} and Gerritsen, {Karin G.} and Vera Jankowski and Joachim Jankowski and Hoenderop, {Joost G. J.} and Rosalinde Masereeuw and Aleksandra Galetin",

year = "2019",

month = nov,

doi = "10.1021/acs.molpharmaceut.9b00681",

language = "English",

volume = "16",

pages = "4551--4562",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

publisher = "American Chemical Society",

number = "11",

}

van der Made, TK, Fedecostante, M, Scotcher, D, Rostami-Hodjegan, A, Torano, JS, Middel, I, Koster, AS, Gerritsen, KG, Jankowski, V, Jankowski, J, Hoenderop, JGJ, Masereeuw, R & Galetin, A 2019, 'Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease', Molecular Pharmaceutics, vol. 16, no. 11, pp. 4551-4562. https://doi.org/10.1021/acs.molpharmaceut.9b00681

Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. / van der Made, Thomas K.; Fedecostante, Michele; Scotcher, Daniel; Rostami-Hodjegan, Amin; Torano, Javier Sastre; Middel, Igor; Koster, Andries S.; Gerritsen, Karin G.; Jankowski, Vera; Jankowski, Joachim; Hoenderop, Joost G. J.; Masereeuw, Rosalinde; Galetin, Aleksandra.

In: Molecular Pharmaceutics, Vol. 16, No. 11, 11.2019, p. 4551-4562.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - van der Made, Thomas K.

AU - Fedecostante, Michele

AU - Scotcher, Daniel

AU - Rostami-Hodjegan, Amin

AU - Torano, Javier Sastre

AU - Middel, Igor

AU - Koster, Andries S.

AU - Gerritsen, Karin G.

AU - Jankowski, Vera

AU - Jankowski, Joachim

AU - Hoenderop, Joost G. J.

AU - Masereeuw, Rosalinde

AU - Galetin, Aleksandra

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KW - in vitro-in vivo extrapolation

KW - CKD

KW - ORGANIC ANION TRANSPORTERS

KW - DRUG-DRUG INTERACTIONS

KW - P-CRESOL SULFATE

KW - II-THE-BRAIN

KW - RENAL CLEARANCE

KW - UREMIC TOXINS

KW - EFFLUX TRANSPORTERS

KW - PLASMA-LEVELS

KW - PROTEIN

KW - PREDICTION

U2 - 10.1021/acs.molpharmaceut.9b00681

DO - 10.1021/acs.molpharmaceut.9b00681

M3 - Article

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VL - 16

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JO - Molecular Pharmaceutics

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