Quantitative performance evaluation of I-124 PET/MRI lesion dosimetry in differentiated thyroid cancer

R. Wierts*, W. Jentzen, H. H. Quick, H. J. Wisselink, I. N. A. Pooters, J. E. Wildberger, K. Herrmann, G. J. Kemerink, W. H. Backes, F. M. Mottaghy

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The aim was to investigate the quantitative performance of I-124 PET/MRI for pre-therapy lesion dosimetry in differentiated thyroid cancer (DTC). Phantom measurements were performed on a PET/MRI system (Biograph mMR, Siemens Healthcare) using 124I and F-18. The PET calibration factor and the influence of radiofrequency coil attenuation were determined using a cylindrical phantom homogeneously filled with radioactivity. The calibration factor was 1.00 +/- 0.02 for F-18 and 0.88 +/- 0.02 for I-124. Near the radiofrequency surface coil an underestimation of less than 5% in radioactivity concentration was observed. Soft-tissue sphere recovery coefficients were determined using the NEMA IEC body phantom. Recovery coefficients were systematically higher for F-18 than for I-124. In addition, the six spheres of the phantom were segmented using a PET-based iterative segmentation algorithm. For all I-124 measurements, the deviations in segmented lesion volume and mean radioactivity concentration relative to the actual values were smaller than 15% and 25%, respectively. The effect of MR-based attenuation correction (three-and four-segment mu-maps) on bone lesion quantification was assessed using radioactive spheres filled with a K2HPO4 solution mimicking bone lesions. The four-segment mu-map resulted in an underestimation of the imaged radioactivity concentration of up to 15%, whereas the three-segment mu-map resulted in an overestimation of up to 10%. For twenty lesions identified in six patients, a comparison of I-124 PET/MRI to PET/CT was performed with respect to segmented lesion volume and radioactivity concentration. The interclass correlation coefficients showed excellent agreement in segmented lesion volume and radioactivity concentration (0.999 and 0.95, respectively). In conclusion, it is feasible that accurate quantitative I-124 PET/MRI could be used to perform radioiodine pre-therapy lesion dosimetry in DTC.
Original languageEnglish
Article number015014
Number of pages10
JournalPhysics in Medicine and Biology
Issue number1
Publication statusPublished - 1 Jan 2018


  • I-124
  • lesion dosimetry
  • radioiodine therapy
  • thyroid carcinoma
  • PET
  • BONE


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