Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

M. M. C. Bruijn; J. Y. Vis; F. F. Wilms; M. A. Oudijk; A. Kwee; M. M. Porath; G. Oei; H. C. J. Scheepers; M. E. A. Spaanderman; K. W. M. Bloemenkamp; M. C. Haak; A. C. Bolte; F. P. H. A. Vandenbussche; M. D. Woiski; C. J. Bax; J. M. J. Cornette; J. J. Duvekot; B. W. A. Nij Bijvanck; J. van Eyck; M. T. M. Franssen; K. M. Sollie; J. A. M. van der Post; P. M. M. Bossuyt; B. C. Opmeer; M. Kok; B. W. J. Mol; G-J van Baaren

doi:10.1111/1471-0528.13752

Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

M. M. C. Bruijn^*, J. Y. Vis, F. F. Wilms, M. A. Oudijk, A. Kwee, M. M. Porath, G. Oei, H. C. J. Scheepers, M. E. A. Spaanderman, K. W. M. Bloemenkamp, M. C. Haak, A. C. Bolte, F. P. H. A. Vandenbussche, M. D. Woiski, C. J. Bax, J. M. J. Cornette, J. J. Duvekot, B. W. A. Nij Bijvanck, J. van Eyck, M. T. M. FranssenK. M. Sollie, J. A. M. van der Post, P. M. M. Bossuyt, B. C. Opmeer, M. Kok, B. W. J. Mol, G-J van Baaren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (

Original language	English
Pages (from-to)	1965-1971
Journal	Bjog-an International Journal of Obstetrics and Gynaecology
Volume	123
Issue number	12
DOIs	https://doi.org/10.1111/1471-0528.13752
Publication status	Published - Nov 2016

Keywords

Cervical length
prediction
pregnancy
preterm labour
quantitative fetal fibronectin

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10.1111/1471-0528.13752

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Bruijn, M. M. C., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Oei, G., Scheepers, H. C. J., Spaanderman, M. E. A., Bloemenkamp, K. W. M., Haak, M. C., Bolte, A. C., Vandenbussche, F. P. H. A., Woiski, M. D., Bax, C. J., Cornette, J. M. J., Duvekot, J. J., Bijvanck, B. W. A. N., van Eyck, J., ... van Baaren, G.-J. (2016). Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. Bjog-an International Journal of Obstetrics and Gynaecology, 123(12), 1965-1971. https://doi.org/10.1111/1471-0528.13752

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title = "Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women",

abstract = "Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (",

keywords = "Cervical length, prediction, pregnancy, preterm labour, quantitative fetal fibronectin",

author = "Bruijn, {M. M. C.} and Vis, {J. Y.} and Wilms, {F. F.} and Oudijk, {M. A.} and A. Kwee and Porath, {M. M.} and G. Oei and Scheepers, {H. C. J.} and Spaanderman, {M. E. A.} and Bloemenkamp, {K. W. M.} and Haak, {M. C.} and Bolte, {A. C.} and Vandenbussche, {F. P. H. A.} and Woiski, {M. D.} and Bax, {C. J.} and Cornette, {J. M. J.} and Duvekot, {J. J.} and Bijvanck, {B. W. A. Nij} and {van Eyck}, J. and Franssen, {M. T. M.} and Sollie, {K. M.} and {van der Post}, {J. A. M.} and Bossuyt, {P. M. M.} and Opmeer, {B. C.} and M. Kok and Mol, {B. W. J.} and {van Baaren}, G-J",

year = "2016",

month = nov,

doi = "10.1111/1471-0528.13752",

language = "English",

volume = "123",

pages = "1965--1971",

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Bruijn, MMC, Vis, JY, Wilms, FF, Oudijk, MA, Kwee, A, Porath, MM, Oei, G, Scheepers, HCJ , Spaanderman, MEA, Bloemenkamp, KWM, Haak, MC, Bolte, AC, Vandenbussche, FPHA, Woiski, MD, Bax, CJ, Cornette, JMJ, Duvekot, JJ, Bijvanck, BWAN, van Eyck, J, Franssen, MTM, Sollie, KM, van der Post, JAM, Bossuyt, PMM, Opmeer, BC, Kok, M, Mol, BWJ & van Baaren, G-J 2016, 'Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women', Bjog-an International Journal of Obstetrics and Gynaecology, vol. 123, no. 12, pp. 1965-1971. https://doi.org/10.1111/1471-0528.13752

Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. / Bruijn, M. M. C.; Vis, J. Y.; Wilms, F. F. et al.
In: Bjog-an International Journal of Obstetrics and Gynaecology, Vol. 123, No. 12, 11.2016, p. 1965-1971.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

AU - Bruijn, M. M. C.

AU - Vis, J. Y.

AU - Wilms, F. F.

AU - Oudijk, M. A.

AU - Kwee, A.

AU - Porath, M. M.

AU - Oei, G.

AU - Scheepers, H. C. J.

AU - Spaanderman, M. E. A.

AU - Bloemenkamp, K. W. M.

AU - Haak, M. C.

AU - Bolte, A. C.

AU - Vandenbussche, F. P. H. A.

AU - Woiski, M. D.

AU - Bax, C. J.

AU - Cornette, J. M. J.

AU - Duvekot, J. J.

AU - Bijvanck, B. W. A. Nij

AU - van Eyck, J.

AU - Franssen, M. T. M.

AU - Sollie, K. M.

AU - van der Post, J. A. M.

AU - Bossuyt, P. M. M.

AU - Opmeer, B. C.

AU - Kok, M.

AU - Mol, B. W. J.

AU - van Baaren, G-J

PY - 2016/11

Y1 - 2016/11

N2 - Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (

AB - Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (

KW - Cervical length

KW - prediction

KW - pregnancy

KW - preterm labour

KW - quantitative fetal fibronectin

U2 - 10.1111/1471-0528.13752

DO - 10.1111/1471-0528.13752

M3 - Article

C2 - 26667313

SN - 1470-0328

VL - 123

SP - 1965

EP - 1971

JO - Bjog-an International Journal of Obstetrics and Gynaecology

JF - Bjog-an International Journal of Obstetrics and Gynaecology

IS - 12

ER -

Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

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Keywords

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