Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

M. M. C. Bruijn*, J. Y. Vis, F. F. Wilms, M. A. Oudijk, A. Kwee, M. M. Porath, G. Oei, H. C. J. Scheepers, M. E. A. Spaanderman, K. W. M. Bloemenkamp, M. C. Haak, A. C. Bolte, F. P. H. A. Vandenbussche, M. D. Woiski, C. J. Bax, J. M. J. Cornette, J. J. Duvekot, B. W. A. Nij Bijvanck, J. van Eyck, M. T. M. FranssenK. M. Sollie, J. A. M. van der Post, P. M. M. Bossuyt, B. C. Opmeer, M. Kok, B. W. J. Mol, G-J van Baaren

*Corresponding author for this work

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30 Citations (Web of Science)

Abstract

Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (
Original languageEnglish
Pages (from-to)1965-1971
JournalBjog-an International Journal of Obstetrics and Gynaecology
Volume123
Issue number12
DOIs
Publication statusPublished - Nov 2016

Keywords

  • Cervical length
  • prediction
  • pregnancy
  • preterm labour
  • quantitative fetal fibronectin

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