Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

M. M. C. Bruijn*, J. Y. Vis, F. F. Wilms, M. A. Oudijk, A. Kwee, M. M. Porath, G. Oei, H. C. J. Scheepers, M. E. A. Spaanderman, K. W. M. Bloemenkamp, M. C. Haak, A. C. Bolte, F. P. H. A. Vandenbussche, M. D. Woiski, C. J. Bax, J. M. J. Cornette, J. J. Duvekot, B. W. A. Nij Bijvanck, J. van Eyck, M. T. M. FranssenK. M. Sollie, J. A. M. van der Post, P. M. M. Bossuyt, B. C. Opmeer, M. Kok, B. W. J. Mol, G-J van Baaren

*Corresponding author for this work

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Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (
Original languageEnglish
Pages (from-to)1965-1971
JournalBjog-an International Journal of Obstetrics and Gynaecology
Issue number12
Publication statusPublished - Nov 2016


  • Cervical length
  • prediction
  • pregnancy
  • preterm labour
  • quantitative fetal fibronectin

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