Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

M. M. C. Bruijn; J. Y. Vis; F. F. Wilms; M. A. Oudijk; A. Kwee; M. M. Porath; G. Oei; H. C. J. Scheepers; M. E. A. Spaanderman; K. W. M. Bloemenkamp; M. C. Haak; A. C. Bolte; F. P. H. A. Vandenbussche; M. D. Woiski; C. J. Bax; J. M. J. Cornette; J. J. Duvekot; B. W. A. Nij Bijvanck; J. van Eyck; M. T. M. Franssen; K. M. Sollie; J. A. M. van der Post; P. M. M. Bossuyt; B. C. Opmeer; M. Kok; B. W. J. Mol; G-J van Baaren

doi:10.1111/1471-0528.13752

Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

M. M. C. Bruijn^*, J. Y. Vis, F. F. Wilms, M. A. Oudijk, A. Kwee, M. M. Porath, G. Oei, H. C. J. Scheepers, M. E. A. Spaanderman, K. W. M. Bloemenkamp, M. C. Haak, A. C. Bolte, F. P. H. A. Vandenbussche, M. D. Woiski, C. J. Bax, J. M. J. Cornette, J. J. Duvekot, B. W. A. Nij Bijvanck, J. van Eyck, M. T. M. FranssenK. M. Sollie, J. A. M. van der Post, P. M. M. Bossuyt, B. C. Opmeer, M. Kok, B. W. J. Mol, G-J van Baaren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (

Original language	English
Pages (from-to)	1965-1971
Journal	Bjog-an International Journal of Obstetrics and Gynaecology
Volume	123
Issue number	12
DOIs	https://doi.org/10.1111/1471-0528.13752
Publication status	Published - Nov 2016

Keywords

Cervical length
prediction
pregnancy
preterm labour
quantitative fetal fibronectin

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10.1111/1471-0528.13752

Cite this

Bruijn, M. M. C., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Oei, G., Scheepers, H. C. J., Spaanderman, M. E. A., Bloemenkamp, K. W. M., Haak, M. C., Bolte, A. C., Vandenbussche, F. P. H. A., Woiski, M. D., Bax, C. J., Cornette, J. M. J., Duvekot, J. J., Bijvanck, B. W. A. N., van Eyck, J., ... van Baaren, G.-J. (2016). Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. Bjog-an International Journal of Obstetrics and Gynaecology, 123(12), 1965-1971. https://doi.org/10.1111/1471-0528.13752

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title = "Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women",

abstract = "Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (",

keywords = "Cervical length, prediction, pregnancy, preterm labour, quantitative fetal fibronectin",

author = "Bruijn, {M. M. C.} and Vis, {J. Y.} and Wilms, {F. F.} and Oudijk, {M. A.} and A. Kwee and Porath, {M. M.} and G. Oei and Scheepers, {H. C. J.} and Spaanderman, {M. E. A.} and Bloemenkamp, {K. W. M.} and Haak, {M. C.} and Bolte, {A. C.} and Vandenbussche, {F. P. H. A.} and Woiski, {M. D.} and Bax, {C. J.} and Cornette, {J. M. J.} and Duvekot, {J. J.} and Bijvanck, {B. W. A. Nij} and {van Eyck}, J. and Franssen, {M. T. M.} and Sollie, {K. M.} and {van der Post}, {J. A. M.} and Bossuyt, {P. M. M.} and Opmeer, {B. C.} and M. Kok and Mol, {B. W. J.} and {van Baaren}, G-J",

year = "2016",

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Bruijn, MMC, Vis, JY, Wilms, FF, Oudijk, MA, Kwee, A, Porath, MM, Oei, G, Scheepers, HCJ , Spaanderman, MEA, Bloemenkamp, KWM, Haak, MC, Bolte, AC, Vandenbussche, FPHA, Woiski, MD, Bax, CJ, Cornette, JMJ, Duvekot, JJ, Bijvanck, BWAN, van Eyck, J, Franssen, MTM, Sollie, KM, van der Post, JAM, Bossuyt, PMM, Opmeer, BC, Kok, M, Mol, BWJ & van Baaren, G-J 2016, 'Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women', Bjog-an International Journal of Obstetrics and Gynaecology, vol. 123, no. 12, pp. 1965-1971. https://doi.org/10.1111/1471-0528.13752

Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. / Bruijn, M. M. C.; Vis, J. Y.; Wilms, F. F. et al.
In: Bjog-an International Journal of Obstetrics and Gynaecology, Vol. 123, No. 12, 11.2016, p. 1965-1971.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

AU - Bruijn, M. M. C.

AU - Vis, J. Y.

AU - Wilms, F. F.

AU - Oudijk, M. A.

AU - Kwee, A.

AU - Porath, M. M.

AU - Oei, G.

AU - Scheepers, H. C. J.

AU - Spaanderman, M. E. A.

AU - Bloemenkamp, K. W. M.

AU - Haak, M. C.

AU - Bolte, A. C.

AU - Vandenbussche, F. P. H. A.

AU - Woiski, M. D.

AU - Bax, C. J.

AU - Cornette, J. M. J.

AU - Duvekot, J. J.

AU - Bijvanck, B. W. A. Nij

AU - van Eyck, J.

AU - Franssen, M. T. M.

AU - Sollie, K. M.

AU - van der Post, J. A. M.

AU - Bossuyt, P. M. M.

AU - Opmeer, B. C.

AU - Kok, M.

AU - Mol, B. W. J.

AU - van Baaren, G-J

PY - 2016/11

Y1 - 2016/11

N2 - Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (

AB - Objective To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting Ten perinatal centres in the Netherlands. Population Symptomatic women between 24 and 34 weeks of gestation. Methods The risk of PTD 500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in 500 ng/ml: OR 39, 95% CI 9.4-164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82-0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (

KW - Cervical length

KW - prediction

KW - pregnancy

KW - preterm labour

KW - quantitative fetal fibronectin

U2 - 10.1111/1471-0528.13752

DO - 10.1111/1471-0528.13752

M3 - Article

C2 - 26667313

SN - 1470-0328

VL - 123

SP - 1965

EP - 1971

JO - Bjog-an International Journal of Obstetrics and Gynaecology

JF - Bjog-an International Journal of Obstetrics and Gynaecology

IS - 12

ER -