Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke

A.M.M. Boers; R.S. Barros; I.G.H. Jansen; C.H. Slump; D.W.J. Dippel; A. van der Lugt; W.H. van Zwam; Y.B.W.E.M. Roos; R.J. van Oostenbrugge; C.B.L.M. Majoie; H.A. Marquering; MR CLEAN Investigators

doi:10.1007/978-3-319-67564-0_18

Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke

A.M.M. Boers^*, R.S. Barros, I.G.H. Jansen, C.H. Slump, D.W.J. Dippel, A. van der Lugt, W.H. van Zwam, Y.B.W.E.M. Roos, R.J. van Oostenbrugge, C.B.L.M. Majoie, H.A. Marquering, MR CLEAN Investigators

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

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Abstract

Reliable assessment of collateral blood supply is important in acute ischemic stroke. We propose a quantitative method for evaluation of collateral status on CT angiography (CTA). We collected CTA images of 70 patients from MR CLEAN with an occlusion in the M1 branch. Our proposed quantitative collateral score (qCS) consisted of atlas-based territory-at-risk identification and vessel segmentation using a Hessian-based filter. Ground truth was obtained by manual collateral scoring (mCS). Accuracy was evaluated by analysis of Spearman ρ and one-way ANOVA. Correlation of mCS and qCS with tissue death and functional outcome was assessed. Receiver operating characteristics curves of mCS and qCS were analyzed to distinguish favorable from unfavorable outcome. qCS strongly correlated with mCS and showed reliable correlations with tissue death and functional outcome. qCS showed higher discriminative power between favorable and unfavorable compared to mCS, indicating potential clinical value.

Original language	English
Title of host publication	MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT
Editors	M. Jorge Cardoso, Tal Arbel
Publisher	Springer International Publishing AG
Pages	176-184
Number of pages	9
Volume	10555
ISBN (Print)	9783319675633
DOIs	https://doi.org/10.1007/978-3-319-67564-0_18
Publication status	Published - 2017
Event	1st Int Workshop on Computat Methods for Mol Imaging (CMMI) / 2nd Int Workshop on Reconstruct & Analysis of Moving Body Organs (RAMBO) / 1st Int Stroke Workshop on Imaging & Treatment Challenges (SWITCH) - , Canada Duration: 10 Sept 2017 → 10 Sept 2017

Publication series

Series	Lecture Notes in Computer Science
Volume	10555
ISSN	0302-9743

Conference

Conference	1st Int Workshop on Computat Methods for Mol Imaging (CMMI) / 2nd Int Workshop on Reconstruct & Analysis of Moving Body Organs (RAMBO) / 1st Int Stroke Workshop on Imaging & Treatment Challenges (SWITCH)
Country/Territory	Canada
Period	10/09/17 → 10/09/17

Keywords

Collateral status
Automatic assessment
Acute ischemic stroke
CT angiography
Endovascular therapy
INTRAARTERIAL TREATMENT
ENDOVASCULAR TREATMENT
OUTCOMES
TRIAL
SCORE
FLOW

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10.1007/978-3-319-67564-0_18

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Boers, A. M. M., Barros, R. S., Jansen, I. G. H., Slump, C. H., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Majoie, C. B. L. M., Marquering, H. A., & MR CLEAN Investigators (2017). Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke. In M. J. Cardoso, & T. Arbel (Eds.), MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT (Vol. 10555, pp. 176-184). Springer International Publishing AG. https://doi.org/10.1007/978-3-319-67564-0_18

Boers, A.M.M. ; Barros, R.S. ; Jansen, I.G.H. et al. / Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke. MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT. editor / M. Jorge Cardoso ; Tal Arbel. Vol. 10555 Springer International Publishing AG, 2017. pp. 176-184 (Lecture Notes in Computer Science, Vol. 10555).

@inproceedings{363f0e2f6c05471187c2fc58d6033021,

title = "Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke",

abstract = "Reliable assessment of collateral blood supply is important in acute ischemic stroke. We propose a quantitative method for evaluation of collateral status on CT angiography (CTA). We collected CTA images of 70 patients from MR CLEAN with an occlusion in the M1 branch. Our proposed quantitative collateral score (qCS) consisted of atlas-based territory-at-risk identification and vessel segmentation using a Hessian-based filter. Ground truth was obtained by manual collateral scoring (mCS). Accuracy was evaluated by analysis of Spearman ρ and one-way ANOVA. Correlation of mCS and qCS with tissue death and functional outcome was assessed. Receiver operating characteristics curves of mCS and qCS were analyzed to distinguish favorable from unfavorable outcome. qCS strongly correlated with mCS and showed reliable correlations with tissue death and functional outcome. qCS showed higher discriminative power between favorable and unfavorable compared to mCS, indicating potential clinical value.",

keywords = "Collateral status, Automatic assessment, Acute ischemic stroke, CT angiography, Endovascular therapy, INTRAARTERIAL TREATMENT, ENDOVASCULAR TREATMENT, OUTCOMES, TRIAL, SCORE, FLOW",

author = "A.M.M. Boers and R.S. Barros and I.G.H. Jansen and C.H. Slump and D.W.J. Dippel and {van der Lugt}, A. and {van Zwam}, W.H. and Y.B.W.E.M. Roos and {van Oostenbrugge}, R.J. and C.B.L.M. Majoie and H.A. Marquering and {MR CLEAN Investigators}",

year = "2017",

doi = "10.1007/978-3-319-67564-0_18",

language = "English",

isbn = "9783319675633",

volume = "10555",

series = "Lecture Notes in Computer Science",

publisher = "Springer International Publishing AG",

pages = "176--184",

editor = "Cardoso, {M. Jorge} and Tal Arbel",

booktitle = "MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT",

note = "1st Int Workshop on Computat Methods for Mol Imaging (CMMI) / 2nd Int Workshop on Reconstruct & Analysis of Moving Body Organs (RAMBO) / 1st Int Stroke Workshop on Imaging & Treatment Challenges (SWITCH) ; Conference date: 10-09-2017 Through 10-09-2017",

}

Boers, AMM, Barros, RS, Jansen, IGH, Slump, CH, Dippel, DWJ, van der Lugt, A, van Zwam, WH, Roos, YBWEM, van Oostenbrugge, RJ, Majoie, CBLM, Marquering, HA & MR CLEAN Investigators 2017, Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke. in MJ Cardoso & T Arbel (eds), MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT. vol. 10555, Springer International Publishing AG, Lecture Notes in Computer Science, vol. 10555, pp. 176-184, 1st Int Workshop on Computat Methods for Mol Imaging (CMMI) / 2nd Int Workshop on Reconstruct & Analysis of Moving Body Organs (RAMBO) / 1st Int Stroke Workshop on Imaging & Treatment Challenges (SWITCH), Canada, 10/09/17. https://doi.org/10.1007/978-3-319-67564-0_18

Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke. / Boers, A.M.M.; Barros, R.S.; Jansen, I.G.H. et al.
MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT. ed. / M. Jorge Cardoso; Tal Arbel. Vol. 10555 Springer International Publishing AG, 2017. p. 176-184 (Lecture Notes in Computer Science, Vol. 10555).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

TY - GEN

T1 - Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke

AU - Boers, A.M.M.

AU - Barros, R.S.

AU - Jansen, I.G.H.

AU - Slump, C.H.

AU - Dippel, D.W.J.

AU - van der Lugt, A.

AU - van Zwam, W.H.

AU - Roos, Y.B.W.E.M.

AU - van Oostenbrugge, R.J.

AU - Majoie, C.B.L.M.

AU - Marquering, H.A.

AU - MR CLEAN Investigators

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Y1 - 2017

N2 - Reliable assessment of collateral blood supply is important in acute ischemic stroke. We propose a quantitative method for evaluation of collateral status on CT angiography (CTA). We collected CTA images of 70 patients from MR CLEAN with an occlusion in the M1 branch. Our proposed quantitative collateral score (qCS) consisted of atlas-based territory-at-risk identification and vessel segmentation using a Hessian-based filter. Ground truth was obtained by manual collateral scoring (mCS). Accuracy was evaluated by analysis of Spearman ρ and one-way ANOVA. Correlation of mCS and qCS with tissue death and functional outcome was assessed. Receiver operating characteristics curves of mCS and qCS were analyzed to distinguish favorable from unfavorable outcome. qCS strongly correlated with mCS and showed reliable correlations with tissue death and functional outcome. qCS showed higher discriminative power between favorable and unfavorable compared to mCS, indicating potential clinical value.

AB - Reliable assessment of collateral blood supply is important in acute ischemic stroke. We propose a quantitative method for evaluation of collateral status on CT angiography (CTA). We collected CTA images of 70 patients from MR CLEAN with an occlusion in the M1 branch. Our proposed quantitative collateral score (qCS) consisted of atlas-based territory-at-risk identification and vessel segmentation using a Hessian-based filter. Ground truth was obtained by manual collateral scoring (mCS). Accuracy was evaluated by analysis of Spearman ρ and one-way ANOVA. Correlation of mCS and qCS with tissue death and functional outcome was assessed. Receiver operating characteristics curves of mCS and qCS were analyzed to distinguish favorable from unfavorable outcome. qCS strongly correlated with mCS and showed reliable correlations with tissue death and functional outcome. qCS showed higher discriminative power between favorable and unfavorable compared to mCS, indicating potential clinical value.

KW - Collateral status

KW - Automatic assessment

KW - Acute ischemic stroke

KW - CT angiography

KW - Endovascular therapy

KW - INTRAARTERIAL TREATMENT

KW - ENDOVASCULAR TREATMENT

KW - OUTCOMES

KW - TRIAL

KW - SCORE

KW - FLOW

U2 - 10.1007/978-3-319-67564-0_18

DO - 10.1007/978-3-319-67564-0_18

M3 - Conference article in proceeding

SN - 9783319675633

VL - 10555

T3 - Lecture Notes in Computer Science

SP - 176

EP - 184

BT - MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT

A2 - Cardoso, M. Jorge

A2 - Arbel, Tal

PB - Springer International Publishing AG

T2 - 1st Int Workshop on Computat Methods for Mol Imaging (CMMI) / 2nd Int Workshop on Reconstruct & Analysis of Moving Body Organs (RAMBO) / 1st Int Stroke Workshop on Imaging & Treatment Challenges (SWITCH)

Y2 - 10 September 2017 through 10 September 2017

ER -

Boers AMM, Barros RS, Jansen IGH, Slump CH, Dippel DWJ, van der Lugt A et al. Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke. In Cardoso MJ, Arbel T, editors, MOLECULAR IMAGING, RECONSTRUCTION AND ANALYSIS OF MOVING BODY ORGANS, AND STROKE IMAGING AND TREATMENT. Vol. 10555. Springer International Publishing AG. 2017. p. 176-184. (Lecture Notes in Computer Science, Vol. 10555). doi: 10.1007/978-3-319-67564-0_18

Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke

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