Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography: A Systematic Review

Aniruddha Agarwal; Rohan Bir Singh; Roel J Erckens; Tos T J M Berendschot; Carroll A B Webers

doi:10.1080/09273948.2022.2115929

Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography: A Systematic Review

Aniruddha Agarwal^*, Rohan Bir Singh, Roel J Erckens, Tos T J M Berendschot, Carroll A B Webers

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

PURPOSE: The purpose of this systematic review is to identify techniques used for quantification of choriocapillaris (CC) flow in eyes with uveitis using optical coherence tomography angiography (OCTA), report reliability and level of correlation with techniques such as indocyanine green angiography (ICGA).

METHODS: A systematic search of several databases was done. The studies were analyzed for techniques of measurement, reliability, and correlation with other modalities. Risk of bias assessment was performed.

RESULTS: Thirteen studies were included. CC vessel density (7 studies) and flow deficit area (4 studies) were the most used indices. There was significant heterogeneity in the studies due to differences in the scan protocol, thresholding strategy, and analysis. Comparison with ICGA was performed by only one study, and reliability indices were reported by only two studies.

CONCLUSION: OCTA is a useful tool to measure the CC vascularity in eyes with uveitis. However, standardized acquisition and analysis protocols are needed.

Original language	English
Pages (from-to)	1792-1803
Number of pages	12
Journal	Ocular Immunology and Inflammation
Volume	31
Issue number	9
Early online date	10 Sept 2022
DOIs	https://doi.org/10.1080/09273948.2022.2115929
Publication status	Published - 21 Oct 2023

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10.1080/09273948.2022.2115929Licence: CC BY-NC-ND

Cite this

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title = "Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography: A Systematic Review",

abstract = "PURPOSE: The purpose of this systematic review is to identify techniques used for quantification of choriocapillaris (CC) flow in eyes with uveitis using optical coherence tomography angiography (OCTA), report reliability and level of correlation with techniques such as indocyanine green angiography (ICGA).METHODS: A systematic search of several databases was done. The studies were analyzed for techniques of measurement, reliability, and correlation with other modalities. Risk of bias assessment was performed.RESULTS: Thirteen studies were included. CC vessel density (7 studies) and flow deficit area (4 studies) were the most used indices. There was significant heterogeneity in the studies due to differences in the scan protocol, thresholding strategy, and analysis. Comparison with ICGA was performed by only one study, and reliability indices were reported by only two studies.CONCLUSION: OCTA is a useful tool to measure the CC vascularity in eyes with uveitis. However, standardized acquisition and analysis protocols are needed.",

author = "Aniruddha Agarwal and Singh, {Rohan Bir} and Erckens, {Roel J} and Berendschot, {Tos T J M} and Webers, {Carroll A B}",

year = "2023",

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doi = "10.1080/09273948.2022.2115929",

language = "English",

volume = "31",

pages = "1792--1803",

journal = "Ocular Immunology and Inflammation",

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publisher = "Routledge/Taylor & Francis Group",

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Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography: A Systematic Review. / Agarwal, Aniruddha; Singh, Rohan Bir; Erckens, Roel J et al.
In: Ocular Immunology and Inflammation, Vol. 31, No. 9, 21.10.2023, p. 1792-1803.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography

T2 - A Systematic Review

AU - Agarwal, Aniruddha

AU - Singh, Rohan Bir

AU - Erckens, Roel J

AU - Berendschot, Tos T J M

AU - Webers, Carroll A B

PY - 2023/10/21

Y1 - 2023/10/21

N2 - PURPOSE: The purpose of this systematic review is to identify techniques used for quantification of choriocapillaris (CC) flow in eyes with uveitis using optical coherence tomography angiography (OCTA), report reliability and level of correlation with techniques such as indocyanine green angiography (ICGA).METHODS: A systematic search of several databases was done. The studies were analyzed for techniques of measurement, reliability, and correlation with other modalities. Risk of bias assessment was performed.RESULTS: Thirteen studies were included. CC vessel density (7 studies) and flow deficit area (4 studies) were the most used indices. There was significant heterogeneity in the studies due to differences in the scan protocol, thresholding strategy, and analysis. Comparison with ICGA was performed by only one study, and reliability indices were reported by only two studies.CONCLUSION: OCTA is a useful tool to measure the CC vascularity in eyes with uveitis. However, standardized acquisition and analysis protocols are needed.

AB - PURPOSE: The purpose of this systematic review is to identify techniques used for quantification of choriocapillaris (CC) flow in eyes with uveitis using optical coherence tomography angiography (OCTA), report reliability and level of correlation with techniques such as indocyanine green angiography (ICGA).METHODS: A systematic search of several databases was done. The studies were analyzed for techniques of measurement, reliability, and correlation with other modalities. Risk of bias assessment was performed.RESULTS: Thirteen studies were included. CC vessel density (7 studies) and flow deficit area (4 studies) were the most used indices. There was significant heterogeneity in the studies due to differences in the scan protocol, thresholding strategy, and analysis. Comparison with ICGA was performed by only one study, and reliability indices were reported by only two studies.CONCLUSION: OCTA is a useful tool to measure the CC vascularity in eyes with uveitis. However, standardized acquisition and analysis protocols are needed.

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