Quantitative Analysis of the Choroidal Vascularity in Eyes with Uveitis Using Optical Coherence Tomography Angiography: A Systematic Review

Aniruddha Agarwal*, Rohan Bir Singh, Roel J Erckens, Tos T J M Berendschot, Carroll A B Webers

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

PURPOSE: The purpose of this systematic review is to identify techniques used for quantification of choriocapillaris (CC) flow in eyes with uveitis using optical coherence tomography angiography (OCTA), report reliability and level of correlation with techniques such as indocyanine green angiography (ICGA).

METHODS: A systematic search of several databases was done. The studies were analyzed for techniques of measurement, reliability, and correlation with other modalities. Risk of bias assessment was performed.

RESULTS: Thirteen studies were included. CC vessel density (7 studies) and flow deficit area (4 studies) were the most used indices. There was significant heterogeneity in the studies due to differences in the scan protocol, thresholding strategy, and analysis. Comparison with ICGA was performed by only one study, and reliability indices were reported by only two studies.

CONCLUSION: OCTA is a useful tool to measure the CC vascularity in eyes with uveitis. However, standardized acquisition and analysis protocols are needed.

Original languageEnglish
Pages (from-to)1792-1803
Number of pages12
JournalOcular Immunology and Inflammation
Volume31
Issue number9
Early online date10 Sept 2022
DOIs
Publication statusPublished - 21 Oct 2023

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