Quantitation of infarct size in man by means of plasma enzyme levels

S.A.G.J. Witteveen; H.C. Hemker; L. Hollaar; W.Th. Hermens

doi:10.1136/hrt.37.8.795

Quantitation of infarct size in man by means of plasma enzyme levels

S.A.G.J. Witteveen, H.C. Hemker, L. Hollaar, W.Th. Hermens

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Abstract

A method is described in which the extent of myocardial infarction in man is assessed by mathematical analysis of the rise in plasma enzyme levels after infarction. Five enzymes are used in this study: lactate dehydrogenase (LDH); alpha-hydroxybutyrate dehydrogenase (alpha-HBDH); aspartate aminotransferase (GOT); creatine phosphokinase (CPK); and phosphohexoseisomerase (PHI). It is shown that a reasonable assessment of the total enzyme release, reflecting the extent of the infarcted area, can be made when a sufficient number of blood samples are taken after infarction. This could provide a method by which to judge therapeutic effects of intervention in the course of a myocardial infarction, as demonstrated in this study by the assessment of the effect of urokinase on the enzyme release after an infarct.

Original language	English
Pages (from-to)	795-803
Number of pages	9
Journal	Heart
Volume	37
Issue number	8
DOIs	https://doi.org/10.1136/hrt.37.8.795
Publication status	Published - 1975

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title = "Quantitation of infarct size in man by means of plasma enzyme levels",

abstract = "A method is described in which the extent of myocardial infarction in man is assessed by mathematical analysis of the rise in plasma enzyme levels after infarction. Five enzymes are used in this study: lactate dehydrogenase (LDH); alpha-hydroxybutyrate dehydrogenase (alpha-HBDH); aspartate aminotransferase (GOT); creatine phosphokinase (CPK); and phosphohexoseisomerase (PHI). It is shown that a reasonable assessment of the total enzyme release, reflecting the extent of the infarcted area, can be made when a sufficient number of blood samples are taken after infarction. This could provide a method by which to judge therapeutic effects of intervention in the course of a myocardial infarction, as demonstrated in this study by the assessment of the effect of urokinase on the enzyme release after an infarct.",

author = "S.A.G.J. Witteveen and H.C. Hemker and L. Hollaar and W.Th. Hermens",

year = "1975",

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T1 - Quantitation of infarct size in man by means of plasma enzyme levels

AU - Witteveen, S.A.G.J.

AU - Hemker, H.C.

AU - Hollaar, L.

AU - Hermens, W.Th.

PY - 1975

Y1 - 1975

N2 - A method is described in which the extent of myocardial infarction in man is assessed by mathematical analysis of the rise in plasma enzyme levels after infarction. Five enzymes are used in this study: lactate dehydrogenase (LDH); alpha-hydroxybutyrate dehydrogenase (alpha-HBDH); aspartate aminotransferase (GOT); creatine phosphokinase (CPK); and phosphohexoseisomerase (PHI). It is shown that a reasonable assessment of the total enzyme release, reflecting the extent of the infarcted area, can be made when a sufficient number of blood samples are taken after infarction. This could provide a method by which to judge therapeutic effects of intervention in the course of a myocardial infarction, as demonstrated in this study by the assessment of the effect of urokinase on the enzyme release after an infarct.

AB - A method is described in which the extent of myocardial infarction in man is assessed by mathematical analysis of the rise in plasma enzyme levels after infarction. Five enzymes are used in this study: lactate dehydrogenase (LDH); alpha-hydroxybutyrate dehydrogenase (alpha-HBDH); aspartate aminotransferase (GOT); creatine phosphokinase (CPK); and phosphohexoseisomerase (PHI). It is shown that a reasonable assessment of the total enzyme release, reflecting the extent of the infarcted area, can be made when a sufficient number of blood samples are taken after infarction. This could provide a method by which to judge therapeutic effects of intervention in the course of a myocardial infarction, as demonstrated in this study by the assessment of the effect of urokinase on the enzyme release after an infarct.

U2 - 10.1136/hrt.37.8.795

DO - 10.1136/hrt.37.8.795

M3 - Article

SN - 1355-6037

VL - 37

SP - 795

EP - 803

JO - Heart

JF - Heart

IS - 8

ER -