Abstract
Purpose: To estimate the effect of reducing intraocular pressure (IOP) on: (i) the incidence of primary open-angle glaucoma (POAG) in patients with ocular hypertension (OH), and (ii) the progression of glaucoma. Methods: A meta-analysis of relevant randomized controlled trials was conducted. A literature search was performed to identify trials with: a randomized comparison of IOP-lowering intervention versus placebo or no treatment; visual field loss or optic disc changes as outcome; and follow-up >6 months. A pooled relative risk (RR) was calculated by a random effects model. Risk reduction of glaucoma conversion per mmHg of IOP reduction was quantified in a meta-regression model. Results: We identified nine OH and one POAG trials. A meta-analysis of OH trials gives a pooled RR of 0.61 [95% confidence interval (CI) 0.45-0.83]. A meta-regression shows a decrease of the RR of glaucoma conversion by 14% with each mmHg extra IOP reduction (P = 0.045). No meta-analysis of POAG trials was performed because only one study has been identified. Conclusion: There is sufficient evidence that OH therapy reduces the risk of conversion to glaucoma. This risk reduction increases with greater IOP reduction.
Original language | English |
---|---|
Pages (from-to) | 5-11 |
Number of pages | 7 |
Journal | Acta Ophthalmologica |
Volume | 88 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2010 |
Keywords
- drugs
- glaucoma
- meta-analysis
- ocular hypertension
- review
- OPEN-ANGLE GLAUCOMA
- RANDOMIZED CLINICAL-TRIALS
- OCULAR HYPERTENSION
- SYSTEMATIC REVIEWS
- MEDICAL-TREATMENT
- TIMOLOL THERAPY
- METAANALYSIS
- MANAGEMENT
- SUSPECTS
- EPINEPHRINE