TY - JOUR
T1 - Quality of Vision After Femtosecond Laser-Assisted Descemet Stripping Endothelial Keratoplasty and Penetrating Keratoplasty: A Randomized, Multicenter Clinical Trial
AU - Cheng, Yanny Y. Y.
AU - van den Berg, Tom J. T. P.
AU - Schouten, Jan S. A. G.
AU - Pels, Elisabeth
AU - Wijdh, Robert-Jan
AU - Van Cleynenbreugel, Hugo
AU - Eggink, Catharina A.
AU - Rijneveld, Wilhelmina J.
AU - Nuijts, Rudy M. M. A.
PY - 2011/10
Y1 - 2011/10
N2 - PURPOSE: To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK). DESIGN: Prospective, randomized clinical trial. METHODS: SETTING: Multicenter (5 ophthalmic centers in The Netherlands). STUDY POPULATION: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. OBSERVATION PROCEDURES: FS DSEK and PK. MAIN OUTCOME MEASURES: Stray light, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score. RESULTS: Stray light at 12 months was 1.37 +/- 0.2 logarithm of straylight for FS DSEK and 1.46 +/- 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P <.001) and PK (P <.001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up. CONCLUSIONS: Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Stray light and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group. (Am J Ophthalmol 2011;152:556-566.
AB - PURPOSE: To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK). DESIGN: Prospective, randomized clinical trial. METHODS: SETTING: Multicenter (5 ophthalmic centers in The Netherlands). STUDY POPULATION: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. OBSERVATION PROCEDURES: FS DSEK and PK. MAIN OUTCOME MEASURES: Stray light, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score. RESULTS: Stray light at 12 months was 1.37 +/- 0.2 logarithm of straylight for FS DSEK and 1.46 +/- 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P <.001) and PK (P <.001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up. CONCLUSIONS: Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Stray light and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group. (Am J Ophthalmol 2011;152:556-566.
U2 - 10.1016/j.ajo.2011.03.012
DO - 10.1016/j.ajo.2011.03.012
M3 - Article
C2 - 21683332
SN - 0002-9394
VL - 152
SP - 556
EP - 566
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 4
ER -