Quality of INR Control and Outcomes Following Venous Thromboembolism

Arlene M. Gallagher, Frank de Vries, Jonathan M. Plumb, Bastian Hass, Andreas Clemens, Tjeerd-Pieter van Staa*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. Material and Methods: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. Results: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with >= 70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to

Original languageEnglish
Pages (from-to)370-378
Number of pages9
JournalClinical and Applied Thrombosis-Hemostasis
Issue number4
Publication statusPublished - 2012
Externally publishedYes


  • coumarins
  • international normalized ratio
  • thromboembolism
  • VTE


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