Abstract
Introduction: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. Material and Methods: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. Results: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with >= 70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to
Original language | English |
---|---|
Pages (from-to) | 370-378 |
Number of pages | 9 |
Journal | Clinical and Applied Thrombosis-Hemostasis |
Volume | 18 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
Keywords
- coumarins
- international normalized ratio
- thromboembolism
- VTE
- DEEP-VEIN THROMBOSIS
- PULMONARY-EMBOLISM
- RISK-FACTORS
- MANAGEMENT
- WARFARIN