QTc interval evaluation in patients with right bundle branch block or bifascicular blocks

Damir Erkapic; Gerrit Frommeyer; Niklas Brettner; Korkut Soezener; Harry J. G. M. Crijns; Melchior Seyfarth; Christian W. Hamm; Harilaos Bogossian

doi:10.1002/clc.23389

QTc interval evaluation in patients with right bundle branch block or bifascicular blocks

Damir Erkapic^*, Gerrit Frommeyer, Niklas Brettner, Korkut Soezener, Harry J. G. M. Crijns, Melchior Seyfarth, Christian W. Hamm, Harilaos Bogossian

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block.

Hypothesis The hypothesis of the present study was to evaluate the feasibility of a simple formula for RBBB and bifascicular block correction, thereby making it easier to determine the QTc interval.

Methods In patients with intrinsic QRS duration

Results A total of scheduled 71 patients were included in this prospective multicenter observational comparative study. Compared to intrinsic QTc interval, the mean Delta QTmc interval by combination of the Bogossian and the Hodge formulas was -3 +/- 24 ms in RBBB + LPFB (P = .44) and -6 +/- 25 ms in RBBB + LAFB (P = .15). The Bogossian formula showed a significant deviation from the actual QTc interval with both the Bazett and the Fridericia formulas.

Conclusion In combination with the Hodge formula, the Boggosian formula delivered the best results in comparing the true QTc interval in narrow QRS with the QTmc interval in the presence of a bifascicular block.

Original language	English
Pages (from-to)	957-962
Number of pages	6
Journal	Clinical Cardiology
Volume	43
Issue number	9
DOIs	https://doi.org/10.1002/clc.23389
Publication status	Published - Sept 2020

Keywords

bifascicular block
Bogossian formula
long QT
QT formula
QT prolongation
right bundle branch block
JT INTERVALS
ASSOCIATION
ARRHYTHMIAS
CARDIOLOGY
FORMULA
RISK

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Cite this

@article{822ebd7fcd2346fba08a933a89e3ae24,

title = "QTc interval evaluation in patients with right bundle branch block or bifascicular blocks",

abstract = "Background The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block.Hypothesis The hypothesis of the present study was to evaluate the feasibility of a simple formula for RBBB and bifascicular block correction, thereby making it easier to determine the QTc interval.Methods In patients with intrinsic QRS durationResults A total of scheduled 71 patients were included in this prospective multicenter observational comparative study. Compared to intrinsic QTc interval, the mean Delta QTmc interval by combination of the Bogossian and the Hodge formulas was -3 +/- 24 ms in RBBB + LPFB (P = .44) and -6 +/- 25 ms in RBBB + LAFB (P = .15). The Bogossian formula showed a significant deviation from the actual QTc interval with both the Bazett and the Fridericia formulas.Conclusion In combination with the Hodge formula, the Boggosian formula delivered the best results in comparing the true QTc interval in narrow QRS with the QTmc interval in the presence of a bifascicular block.",

keywords = "bifascicular block, Bogossian formula, long QT, QT formula, QT prolongation, right bundle branch block, JT INTERVALS, ASSOCIATION, ARRHYTHMIAS, CARDIOLOGY, FORMULA, RISK",

author = "Damir Erkapic and Gerrit Frommeyer and Niklas Brettner and Korkut Soezener and Crijns, {Harry J. G. M.} and Melchior Seyfarth and Hamm, {Christian W.} and Harilaos Bogossian",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.",

year = "2020",

month = sep,

doi = "10.1002/clc.23389",

language = "English",

volume = "43",

pages = "957--962",

journal = "Clinical Cardiology",

issn = "0160-9289",

publisher = "Wiley",

number = "9",

}

TY - JOUR

T1 - QTc interval evaluation in patients with right bundle branch block or bifascicular blocks

AU - Erkapic, Damir

AU - Frommeyer, Gerrit

AU - Brettner, Niklas

AU - Soezener, Korkut

AU - Crijns, Harry J. G. M.

AU - Seyfarth, Melchior

AU - Hamm, Christian W.

AU - Bogossian, Harilaos

PY - 2020/9

Y1 - 2020/9

N2 - Background The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block.Hypothesis The hypothesis of the present study was to evaluate the feasibility of a simple formula for RBBB and bifascicular block correction, thereby making it easier to determine the QTc interval.Methods In patients with intrinsic QRS durationResults A total of scheduled 71 patients were included in this prospective multicenter observational comparative study. Compared to intrinsic QTc interval, the mean Delta QTmc interval by combination of the Bogossian and the Hodge formulas was -3 +/- 24 ms in RBBB + LPFB (P = .44) and -6 +/- 25 ms in RBBB + LAFB (P = .15). The Bogossian formula showed a significant deviation from the actual QTc interval with both the Bazett and the Fridericia formulas.Conclusion In combination with the Hodge formula, the Boggosian formula delivered the best results in comparing the true QTc interval in narrow QRS with the QTmc interval in the presence of a bifascicular block.

AB - Background The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block.Hypothesis The hypothesis of the present study was to evaluate the feasibility of a simple formula for RBBB and bifascicular block correction, thereby making it easier to determine the QTc interval.Methods In patients with intrinsic QRS durationResults A total of scheduled 71 patients were included in this prospective multicenter observational comparative study. Compared to intrinsic QTc interval, the mean Delta QTmc interval by combination of the Bogossian and the Hodge formulas was -3 +/- 24 ms in RBBB + LPFB (P = .44) and -6 +/- 25 ms in RBBB + LAFB (P = .15). The Bogossian formula showed a significant deviation from the actual QTc interval with both the Bazett and the Fridericia formulas.Conclusion In combination with the Hodge formula, the Boggosian formula delivered the best results in comparing the true QTc interval in narrow QRS with the QTmc interval in the presence of a bifascicular block.

KW - bifascicular block

KW - Bogossian formula

KW - long QT

KW - QT formula

KW - QT prolongation

KW - right bundle branch block

KW - JT INTERVALS

KW - ASSOCIATION

KW - ARRHYTHMIAS

KW - CARDIOLOGY

KW - FORMULA

KW - RISK

U2 - 10.1002/clc.23389

DO - 10.1002/clc.23389

M3 - Article

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JO - Clinical Cardiology

JF - Clinical Cardiology

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ER -