Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats

Sarah D'Haese, Lisa Claes, Eva Jaeken, Dorien Deluyker, Lize Evens, Ellen Heeren, Sibren Haesen, Lotte Vastmans, Ivo Lambrichts, Kristiaan Wouters, Casper G Schalkwijk, Dominique Hansen, B O Eijnde, Virginie Bito*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Individuals with type 2 diabetes mellitus (T2DM) are at an increased risk for heart failure, yet preventive cardiac care is suboptimal in this population. Pyridoxamine (PM), a vitamin B 6 analog, has been shown to exert protective effects in metabolic and cardiovascular diseases. In this study, we aimed to investigate whether PM limits adverse cardiac remodeling and dysfunction in rats who develop T2DM. Male rats received a standard chow diet or Western diet (WD) for 18 weeks to induce prediabetes. One WD group received additional PM (1 g/L) via drinking water. Glucose tolerance was assessed with a 1 h oral glucose tolerance test. Cardiac function was evaluated using echocardiography and hemodynamic measurements. Histology on left ventricular (LV) tissue was performed. Treatment with PM prevented the increase in fasting plasma glucose levels compared to WD-fed rats (p < 0.05). LV cardiac dilation tended to be prevented using PM supplementation. In LV tissue, PM limited an increase in interstitial collagen deposition (p < 0.05) seen in WD-fed rats. PM tended to decrease 3-nitrotyrosine and significantly lowered 4-hydroxynonenal content compared to WD-fed rats. We conclude that PM alleviates interstitial fibrosis and oxidative stress in the hearts of WD-induced prediabetic rats.

Original languageEnglish
Article number8508
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume25
Issue number15
DOIs
Publication statusPublished - 4 Aug 2024

Keywords

  • Western diet
  • adverse cardiac remodeling
  • cardioprotection
  • prevention
  • pyridoxamine
  • type 2 diabetes
  • Animals
  • Oxidative Stress/drug effects
  • Fibrosis
  • Male
  • Rats
  • Prediabetic State/drug therapy metabolism etiology
  • Pyridoxamine/pharmacology
  • Diet, Western/adverse effects
  • Myocardium/metabolism pathology
  • Diabetes Mellitus, Type 2/metabolism drug therapy
  • Blood Glucose/metabolism

Fingerprint

Dive into the research topics of 'Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats'. Together they form a unique fingerprint.

Cite this