Pulmonary vein isolation in a real-world population does not influence QTc interval

Ben J. M. Hermans, Matthias D. Zink, Frank van Rosmalen, Harry J. G. M. Crijns, Kevin Vernooy, Pieter Postema, Laurent Pison, Ulrich Schotten, Tammo Delhaas*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aims We aimed to examine whether routine pulmonary vein isolation (PVI) induces significant ventricular repolarization changes as suggested earlier.

Methods and Results Five-minute electrocardiograms were recorded at hospital's admission (T-1d), 1 day after the PVI-procedure (T+1d) and at 3 months post-procedure (T+3m) from a registry of consecutive atrial fibrillation (AF) patients scheduled for routine PVI with different PVI modalities (radiofrequency, cryo-ablation, and hybrid). Only patients who were in sinus rhythm at all three recordings (n=117) were included. QT-intervals and QT-dispersion were evaluated with custom-made software and QTc was calculated using Bazett's, Fridericia's, Framingham's, and Hodges' formulas. Both QT- and RR-intervals were significantly shorter at T+1d (399 +/- 37 and 870 +/- 141 ms) and T+3m (407 +/- 36 and 950 +/- 140ms) compared with baseline (417 +/- 36 and 1025 +/- 164 ms). There was no statistically significant within-subject difference in QTc Fridericia (T-(1d) 416 +/- 28 ms, T+1d 419 +/- 33 ms, and T(+3m)414 +/- 25 ms) and QT-dispersion (T-(1d)18 +/- 12ms, T+1d 21 +/- 19 ms, and T+3m 17 +/- 12 ms) between the recordings. A multiple linear regression model with age, sex, AF type, ablation technique, first/re-do ablation, and AF recurrence to predict the change in QTc at T+3m with respect to QTc at T-1d did not reach significance which indicates that the change in QTc does not differ between all subgroups (age, sex, AF type, ablation technique, first/re-do ablation, and AF recurrence).

Conclusion Based on our data a routine PVI does not result in a prolongation of QTc in a real-world population. These findings, therefore, suggest that there is no need to intensify post-PVI QT-interval monitoring.

Original languageEnglish
Pages (from-to)I48-I54
Number of pages7
JournalEP Europace
Publication statusPublished - Mar 2021


  • Ablation
  • Arrhythmia
  • Atrial fibrillation
  • Pulmonary vein isolation
  • QT-dispersion
  • QT-interval
  • QTc

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