Pulmonary Rehabilitation Reduces Subjective Fatigue in COPD: A Responder Analysis

Maarten Van Herck*, Jeanine Antons, Jan H. Vercoulen, Yvonne M. J. Goertz, Zjala Ebadi, Chris Burtin, Daisy J. A. Janssen, Melissa S. Y. Thong, Jacqueline Otker, Arnold Coors, Mirjam A. G. Sprangers, Jean W. M. Muris, Judith B. Prins, Martijn A. Spruit, Jeannette B. Peters, FAntasTIGUE Consortium

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


To date, it remains unknown which patients report a clinically-relevant improvement in fatigue following pulmonary rehabilitation (PR). The purpose of this study was to identify and characterize these responders. Demographics, lung function, anxiety (anxiety subscale of the 90-item symptom checklist (SCL-90-A)), depression (Beck depression inventory for primary care (BDI-PC)), exercise tolerance (six-minute walking distance test (6MWD)), and health status (Nijmegen clinical screening instrument (NCSI)) were assessed before and after a 12-week PR programme. Fatigue was assessed using the checklist individual strength (CIS)-Fatigue. Patients with a decline >= 10 points (minimally clinically important difference, MCID) on the CIS-Fatigue were defined as responders. Chronic obstructive pulmonary disease (COPD) patients (n = 446, 61 +/- 9 years, 53% male, forced expiratory volume in 1 s (FEV1) 43% +/- 18% predicted, 75% severe fatigue) were included. Mean change in fatigue after PR was 10 +/- 12 points (p <0.01) and exceeded the MCID. In total, 56% were identified as fatigue responders. Baseline CIS-Fatigue (45 +/- 7 vs. 38 +/- 9 points, respectively, p <0.001) and health-related quality-of-life (HRQoL; p <0.001) were different between responders and non-responders. No differences were found in demographics, baseline anxiety, depression, lung function, 6MWD, and dyspnoea (p-values > 0.01). Responders on fatigue reported a greater improvement in anxiety, depression, 6MWD, dyspnoea (all p-values <0.001), and most health status parameters. PR reduces fatigue in COPD. Responders on fatigue have worse fatigue and HRQoL scores at baseline, and are also likely to be responders on other outcomes of PR.

Original languageEnglish
Article number1264
Number of pages14
JournalJournal of Clinical Medicine
Issue number8
Publication statusPublished - Aug 2019


  • pulmonary rehabilitation
  • COPD
  • fatigue
  • quality of life
  • responder analysis


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