Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

L.A. van Tuijl; A.C. Voogd; A. de Graeff; A.W. Hoogendoorn; A.V. Ranchor; K.Y. Pan; M. Basten; F. Lamers; M.I. Geerlings; J.G. Abell; P. Awadalla; M.F. Bakker; A.T.F. Beekman; O. Bjerkeset; A. Boyd; Y.S. Cui; H. Galenkamp; B. Garssen; S. Hellingman; M. Huisman; A. Huss; M.R. Keats; A.A.L. Kok; A.I. Luik; N. Noisel; N.C. Onland-Moret; Y. Payette; B.W.J.H. Penninx; L. Portengen; I. Rissanen; A.M. Roest; J.G.M. Rosmalen; R. Ruiter; R.A. Schoevers; D.M. Soave; M. Spaan; A. Steptoe; K. Stronks; E.R. Sund; E. Sweeney; A. Teyhan; I. Vaartjes; K.D. van der Willik; F.E. van Leeuwen; R. van Petersen; W.M.M. Verschuren; F. Visseren; R. Vermeulen; J. Dekker

doi:10.1002/brb3.2340

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

L.A. van Tuijl^*, A.C. Voogd, A. de Graeff, A.W. Hoogendoorn, A.V. Ranchor, K.Y. Pan, M. Basten, F. Lamers, M.I. Geerlings, J.G. Abell, P. Awadalla, M.F. Bakker, A.T.F. Beekman, O. Bjerkeset, A. Boyd, Y.S. Cui, H. Galenkamp, B. Garssen, S. Hellingman, M. HuismanA. Huss, M.R. Keats, A.A.L. Kok, A.I. Luik, N. Noisel, N.C. Onland-Moret, Y. Payette, B.W.J.H. Penninx, L. Portengen, I. Rissanen, A.M. Roest, J.G.M. Rosmalen, R. Ruiter, R.A. Schoevers, D.M. Soave, M. Spaan, A. Steptoe, K. Stronks, E.R. Sund, E. Sweeney, A. Teyhan, I. Vaartjes, K.D. van der Willik, F.E. van Leeuwen, R. van Petersen, W.M.M. Verschuren, F. Visseren, R. Vermeulen, J. Dekker

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Original language	English
Article number	e2340
Number of pages	13
Journal	Brain and Behavior
Volume	11
Issue number	10
Early online date	2 Sept 2021
DOIs	https://doi.org/10.1002/brb3.2340
Publication status	Published - Oct 2021

Keywords

cancer risk
depression
health behaviors
meta-analysis
psycho-oncology
COHORT PROFILE
COLORECTAL-CANCER
OVARIAN STIMULATION
ALCOHOL-CONSUMPTION
SAMPLE-SIZE
DEPRESSION
RISK
HEALTH
RATIONALE
ANXIETY

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van Tuijl, L. A., Voogd, A. C., de Graeff, A., Hoogendoorn, A. W., Ranchor, A. V., Pan, K. Y., Basten, M., Lamers, F., Geerlings, M. I., Abell, J. G., Awadalla, P., Bakker, M. F., Beekman, A. T. F., Bjerkeset, O., Boyd, A., Cui, Y. S., Galenkamp, H., Garssen, B., Hellingman, S., ... Dekker, J. (2021). Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses. Brain and Behavior, 11(10), Article e2340. https://doi.org/10.1002/brb3.2340

@article{6fc2903346e340f789b6424f8650b0ad,

title = "Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses",

abstract = "Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.",

keywords = "cancer risk, depression, health behaviors, meta-analysis, psycho-oncology, COHORT PROFILE, COLORECTAL-CANCER, OVARIAN STIMULATION, ALCOHOL-CONSUMPTION, SAMPLE-SIZE, DEPRESSION, RISK, HEALTH, RATIONALE, ANXIETY",

author = "{van Tuijl}, L.A. and A.C. Voogd and {de Graeff}, A. and A.W. Hoogendoorn and A.V. Ranchor and K.Y. Pan and M. Basten and F. Lamers and M.I. Geerlings and J.G. Abell and P. Awadalla and M.F. Bakker and A.T.F. Beekman and O. Bjerkeset and A. Boyd and Y.S. Cui and H. Galenkamp and B. Garssen and S. Hellingman and M. Huisman and A. Huss and M.R. Keats and A.A.L. Kok and A.I. Luik and N. Noisel and N.C. Onland-Moret and Y. Payette and B.W.J.H. Penninx and L. Portengen and I. Rissanen and A.M. Roest and J.G.M. Rosmalen and R. Ruiter and R.A. Schoevers and D.M. Soave and M. Spaan and A. Steptoe and K. Stronks and E.R. Sund and E. Sweeney and A. Teyhan and I. Vaartjes and {van der Willik}, K.D. and {van Leeuwen}, F.E. and {van Petersen}, R. and W.M.M. Verschuren and F. Visseren and R. Vermeulen and J. Dekker",

note = "Funding Information: The PSY‐CA consortium is supported by funding from the Dutch Cancer Society(VU2017‐8288). Publisher Copyright: {\textcopyright} 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC",

year = "2021",

month = oct,

doi = "10.1002/brb3.2340",

language = "English",

volume = "11",

journal = "Brain and Behavior",

issn = "2162-3279",

publisher = "John Wiley & Sons Inc.",

number = "10",

}

van Tuijl, LA, Voogd, AC, de Graeff, A, Hoogendoorn, AW, Ranchor, AV, Pan, KY, Basten, M, Lamers, F, Geerlings, MI, Abell, JG, Awadalla, P, Bakker, MF, Beekman, ATF, Bjerkeset, O, Boyd, A, Cui, YS, Galenkamp, H, Garssen, B, Hellingman, S, Huisman, M, Huss, A, Keats, MR, Kok, AAL, Luik, AI, Noisel, N, Onland-Moret, NC, Payette, Y, Penninx, BWJH, Portengen, L, Rissanen, I, Roest, AM, Rosmalen, JGM, Ruiter, R, Schoevers, RA, Soave, DM, Spaan, M, Steptoe, A, Stronks, K, Sund, ER, Sweeney, E, Teyhan, A, Vaartjes, I, van der Willik, KD, van Leeuwen, FE, van Petersen, R, Verschuren, WMM, Visseren, F, Vermeulen, R & Dekker, J 2021, 'Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses', Brain and Behavior, vol. 11, no. 10, e2340. https://doi.org/10.1002/brb3.2340

TY - JOUR

T1 - Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

AU - van Tuijl, L.A.

AU - Voogd, A.C.

AU - de Graeff, A.

AU - Hoogendoorn, A.W.

AU - Ranchor, A.V.

AU - Pan, K.Y.

AU - Basten, M.

AU - Lamers, F.

AU - Geerlings, M.I.

AU - Abell, J.G.

AU - Awadalla, P.

AU - Bakker, M.F.

AU - Beekman, A.T.F.

AU - Bjerkeset, O.

AU - Boyd, A.

AU - Cui, Y.S.

AU - Galenkamp, H.

AU - Garssen, B.

AU - Hellingman, S.

AU - Huisman, M.

AU - Huss, A.

AU - Keats, M.R.

AU - Kok, A.A.L.

AU - Luik, A.I.

AU - Noisel, N.

AU - Onland-Moret, N.C.

AU - Payette, Y.

AU - Penninx, B.W.J.H.

AU - Portengen, L.

AU - Rissanen, I.

AU - Roest, A.M.

AU - Rosmalen, J.G.M.

AU - Ruiter, R.

AU - Schoevers, R.A.

AU - Soave, D.M.

AU - Spaan, M.

AU - Steptoe, A.

AU - Stronks, K.

AU - Sund, E.R.

AU - Sweeney, E.

AU - Teyhan, A.

AU - Vaartjes, I.

AU - van der Willik, K.D.

AU - van Leeuwen, F.E.

AU - van Petersen, R.

AU - Verschuren, W.M.M.

AU - Visseren, F.

AU - Vermeulen, R.

AU - Dekker, J.

N1 - Funding Information: The PSY‐CA consortium is supported by funding from the Dutch Cancer Society(VU2017‐8288). Publisher Copyright: © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC

PY - 2021/10

Y1 - 2021/10

N2 - Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

AB - Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

KW - cancer risk

KW - depression

KW - health behaviors

KW - meta-analysis

KW - psycho-oncology

KW - COHORT PROFILE

KW - COLORECTAL-CANCER

KW - OVARIAN STIMULATION

KW - ALCOHOL-CONSUMPTION

KW - SAMPLE-SIZE

KW - DEPRESSION

KW - RISK

KW - HEALTH

KW - RATIONALE

KW - ANXIETY

U2 - 10.1002/brb3.2340

DO - 10.1002/brb3.2340

M3 - Article

C2 - 34473425

SN - 2162-3279

VL - 11

JO - Brain and Behavior

JF - Brain and Behavior

IS - 10

M1 - e2340

ER -