Abstract
Background Previous studies have indicated decreased health-related quality of life (HRQoL) shortly after kidney donation, returning to baseline in the longer term. However, a subgroup of donors experiences persistent HRQoL problems. To identify which HRQoL aspects are impacted most by the donation and to identify at-risk donors, more specific insight into psychosocial donation consequences is needed.
Methods The current study examined the HRQoL course, donor-perceived consequences of donation for donors, recipients and donor-recipient relationships, and regret up to 12months post-donation in donors from seven Dutch transplantation centres. Kidney donor candidates (n=588) completed self-report questionnaires early in the screening procedure, of which 361 (61%) donated their kidney.
Results Data for 230 donors (64%) with complete assessments before donation and 6 and 12months post-donation were analysed. Results indicated that donor physical HRQoL was comparable at all time points, except for an increase in fatigue that lasted up to 12months post-donation. Mental HRQoL decreased at 6months post-donation, but returned to baseline at 12months. Donors reported large improvements in recipient's functioning and a smaller influence of the recipient's kidney disease or transplantation on the donor's life over time. A subgroup experienced negative donation consequences with 14% experiencing regret 12months post-donation. Predictors of regret were more negative health perceptions and worse social functioning 6months post-donation. The strongest baseline predictors of higher fatigue levels after donation were more pre-donation fatigue, worse general physical functioning and a younger age.
Conclusions Future research should examine predictors of HRQoL after donation to improve screening and to provide potential interventions in at-risk donors.
Original language | English |
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Pages (from-to) | 1045-1055 |
Number of pages | 11 |
Journal | Nephrology Dialysis Transplantation |
Volume | 34 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2019 |
Keywords
- course
- donation consequences
- health-related quality of life
- living kidney donors
- regret
- LONG-TERM
- FOLLOW-UP
- DECISION REGRET
- NEPHRECTOMY
- OUTCOMES
- TRANSPLANTATION
- EXPERIENCES
- PREDICTORS
- FATIGUE
- COHORT