Information on the psychometric properties of the Coping Inventory for Stressful Situations (CISS) in acquired brain injury (ABI) is currently unavailable. Therefore, we investigated the construct and discriminant, convergent, and divergent validity of the CISS in a Dutch adult sample with newly ABI (N = 139). Patients were recruited at the start of outpatient neurorehabilitation (time since diagnosis </= 4 months) or after discharge home from hospital or inpatient neurorehabilitation. The original 3-factor solution of the CISS (Task-Oriented, Emotion-Oriented, Avoidance) showed a borderline fit, which slightly improved after removal of 3 problematic items. We found borderline support for a 4-factor model. Internal consistency was good. Discriminant validity was only partial as we found a moderate correlation between the Task-Oriented and Avoidance scales. Emotion-Oriented Coping correlated strongly with the anxiety and depression subscale of the Hospital Anxiety and Depression Scale. Of the 2 scales of the Assimilative/Accommodative Coping Questionnaire, Tenacious Goal Pursuit correlated strongest with Task-Oriented Coping, whereas Flexible Goal Adjustment correlated negatively with Emotion-Oriented Coping. In summary, the psychometric properties of the CISS in patients with ABI ranged from acceptable to good. The classical 3-factor structure is appropriate, but some items might be problematic in patients with ABI. Replication of the restricted 3-factor model in larger samples is needed, together with further exploration of discriminant validity and the relationship of the CISS with other coping measures, but for now we recommend using the original CISS in patients with ABI. (PsycINFO Database Record (c) 2014 APA, all rights reserved).