Psychiatric manifestations and psychopharmacology of autoimmune encephalitis: A multidisciplinary approach

Jan N.M. Schieveld*, Jacqueline J.M.H. Strik, Suzanne van Kraaij, Joost Nicolai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2 Citations (Web of Science)


The clinical presentations of autoimmune encephalitides tend to be a mixture of neuropsychiatric and somatic symptoms. The focus of this chapter concerns these clinical problems: the clinical phenomenology, the prevalence, and the possible pathophysiologies of anti-NMDAR or the other types of autoimmune encephalitis. We also specifically address the psychopharmacologic and nonpsychopharmacologic treatments. Our main questions are: What are the most used and best justified drug treatments? What are the most frequent side effects? And which other treatment options, such as ECT, are available? We discuss the main findings, present limitations, and we conclude by giving recommendations and presenting two algorithms.

Original languageEnglish
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier BV
Number of pages23
ISBN (Print)978-0-444-64012-3
Publication statusPublished - 2019

Publication series

SeriesHandbook of Clinical Neurology

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