TY - JOUR
T1 - PS6 - 4. Toward selective targeting of muscular AMPK: in search of a small molecule to change AMPK cellular localization
AU - Miglianico, Marie
AU - Oligschläger, Yvonne
AU - Chanda, Dipanjan
AU - Bleylevens, Ivo
AU - Nicolaes, Gerry
AU - Neumann, Dietbert
PY - 2013/11/1
Y1 - 2013/11/1
N2 - The energy-sensor amp-activated protein kinase (ampk) cycles between a glycogen-bound and a free state. The muscle-specific regulatory ampkβ2 subunit carries a high affinity carbohydrate-binding module (cbm). Upon energy stress, such as exercise, ampk localization at glycogen allows for rapid inhibition of glycogen synthesis, whereas cytosolic ampk is capable of stimulating insulin-independent glucose uptake.
AB - The energy-sensor amp-activated protein kinase (ampk) cycles between a glycogen-bound and a free state. The muscle-specific regulatory ampkβ2 subunit carries a high affinity carbohydrate-binding module (cbm). Upon energy stress, such as exercise, ampk localization at glycogen allows for rapid inhibition of glycogen synthesis, whereas cytosolic ampk is capable of stimulating insulin-independent glucose uptake.
U2 - 10.1007/s12467-013-0092-9
DO - 10.1007/s12467-013-0092-9
M3 - Conference Abstract/Poster in journal
SN - 1567-2743
VL - 11
SP - 151
EP - 151
JO - Nederlands Tijdschrift voor Diabetologie
JF - Nederlands Tijdschrift voor Diabetologie
IS - 4
ER -