PS6 - 4. Toward selective targeting of muscular AMPK: in search of a small molecule to change AMPK cellular localization

Marie Miglianico*, Yvonne Oligschläger, Dipanjan Chanda, Ivo Bleylevens, Gerry Nicolaes, Dietbert Neumann

*Corresponding author for this work

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Abstract

The energy-sensor amp-activated protein kinase (ampk) cycles between a glycogen-bound and a free state. The muscle-specific regulatory ampkβ2 subunit carries a high affinity carbohydrate-binding module (cbm). Upon energy stress, such as exercise, ampk localization at glycogen allows for rapid inhibition of glycogen synthesis, whereas cytosolic ampk is capable of stimulating insulin-independent glucose uptake.
Original languageEnglish
Pages (from-to)151-151
JournalNederlands Tijdschrift voor Diabetologie
Volume11
Issue number4
DOIs
Publication statusPublished - 1 Nov 2013

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