Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

Martin Krssak*, Lucas Lindeboom, Vera Schrauwen-Hinderling, Lidia S. Szczepaniak, Wim Derave, Jesper Lundbom, Douglas Befroy, Fritz Schick, Juergen Machann, Roland Kreis, Chris Boesch

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

18 Citations (Web of Science)

Abstract

H-1-MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to the special application of H-1-MRS in skeletal muscle. The highly organized structure of skeletal muscle leads to effects that change spectral features far beyond simple peak heights, depending on the type and orientation of the muscle. Specific recommendations are given for the acquisition of three particular metabolites (intramyocellular lipids, carnosine and acetylcarnitine) and for preconditioning of experiments and instructions to study volunteers.

Original languageEnglish
Article number4266
Number of pages20
JournalNmr in Biomedicine
Volume34
Issue number5
Early online date5 Feb 2020
DOIs
Publication statusPublished - May 2021

Keywords

  • acetylacarnitine
  • carnosine
  • deoxymyoglobine
  • intramyocellular lipids
  • lactate
  • magnetic resonance spectroscopy
  • physiology
  • skeletal muscle
  • BETA-ALANINE SUPPLEMENTATION
  • INTRAMYOCELLULAR LIPID-CONTENT
  • H-1 MR SPECTRA
  • IN-VIVO
  • INSULIN-RESISTANCE
  • NONINVASIVE ASSESSMENT
  • TRIGLYCERIDE CONTENT
  • EXERCISE INTENSITY
  • GLUCOSE-TOLERANCE
  • RELAXATION-TIMES

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