Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis

Alejandro M. Gomez, Annelies Vanheel, Mario Losen, Peter C. Molenaar, Marc H. De Baets, Jean-Paul Noben, Niels Hellings, Pilar Martinez-Martinez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscles proteomic profile at different stages of experimental autoimmune myasthenia gravis (EAMG). We identified twenty-two differentially expressed proteins, mainly related to metabolic and stress-response pathways. Interestingly, these identified proteins have also been associated with other contraction-impairing muscle pathologies (e.g. inclusion body myositis), suggesting a similar response of the muscle to such conditions.
Original languageEnglish
Pages (from-to)141-145
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 15 Aug 2013


  • Myasthenia gravis
  • Muscle proteomics
  • 2D-DIGE
  • Autoimmunity

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