Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients

R.J. Manders*, D. Hansen, A.H.G. Zorenc, P. Dendale, J. Kloek, W.H. Saris, L.J. van Loon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Abstract The capacity of nutritional protein to induce endogenous insulin secretion has been well established. However, it is not known whether such a response is applicable in a diverse population of type 2 diabetes patients. The aim of the present study was to assess the impact of co-ingesting either intact or hydrolyzed protein with carbohydrate on postprandial plasma insulin and glucose responses in type 2 diabetes patients. Sixty longstanding, male, type 2 diabetes patients participated in a study in which we determined postprandial plasma insulin and glucose responses after ingesting a single bolus of carbohydrate (0.7 g/kg: CHO) with or without an intact protein (0.3 g/kg: PRO) or its hydrolysate (0.3 g/kg: PROh). Results showed that protein co-ingestion strongly increased postprandial insulin release, with the insulin response +99+/-41 and +110+/-10% greater in the CHO+PRO and CHO+PROh experiments when compared with the CHO experiment. The insulinotropic properties of protein co-ingestion were evident in nearly all patients, with 58 out of 60 patients responding >10% when compared with the insulin response following carbohydrate ingestion only (CHO). The concomitant plasma glucose responses were 22+/-32 and 23+/-36% lower in the CHO+PRO and CHO+PROh experiments, respectively. We conclude that protein co-ingestion represents an effective dietary strategy to strongly augment postprandial insulin release and attenuate the postprandial rise in glucose concentration in type 2 diabetes patients.
Original languageEnglish
Pages (from-to)758-763
JournalJournal of Medicinal Food
Issue number7
Publication statusPublished - 1 Jan 2014

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