Protein biomarkers in chronic disease : proteomics-driven discovery

B. Pulinx

doi:10.26481/dis.20121003bp

Protein biomarkers in chronic disease : proteomics-driven discovery

B. Pulinx

DA CDL Algemeen

Research output: Thesis › Doctoral Thesis › Internal

664 Downloads (Pure)

Abstract

For this dissertation proteomics techniques were used to find new/better biomarkers for aneurisms of the abdominal aorta (AAA), Multiple Sclerosis (MS) and the quality of donor kidneys. It is shown that certain proteins in the blood are associated with AAA size and growth, and can be helpful in determining a successful surgical intervention to treat the AAA. Moreover, in the perfusion liquid of donor kidneys proteins were found that are an indication for the vital strength of the transplant and the degree of protein glycation in the cerebrospinal liquid, which can play a role in unravelling the development of MS.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Visser - van Dieijen, Marja, Supervisor Schurink, Gerardus, Supervisor Wodzig, Will, Co-Supervisor
Award date	3 Oct 2012
Place of Publication	Maastricht
Publisher	Maastricht University
DOIs	https://doi.org/10.26481/dis.20121003bp
Publication status	Published - 1 Jan 2012

Keywords

Biomarkers
Proteomics
abdominal aorta aneurysm (AAA)
Multiple Sclerosis (MS)
Donor kidneys

Access to Document

10.26481/dis.20121003bp

Full TextFinal published version, 1.32 MB
CoverFinal published version, 59.2 KB
AbstractFinal published version, 107 KB
PropositionsFinal published version, 50.2 KB

Cite this

@phdthesis{0793d30bc6654ecf8c18d438859c77fd,

title = "Protein biomarkers in chronic disease : proteomics-driven discovery",

abstract = "For this dissertation proteomics techniques were used to find new/better biomarkers for aneurisms of the abdominal aorta (AAA), Multiple Sclerosis (MS) and the quality of donor kidneys. It is shown that certain proteins in the blood are associated with AAA size and growth, and can be helpful in determining a successful surgical intervention to treat the AAA. Moreover, in the perfusion liquid of donor kidneys proteins were found that are an indication for the vital strength of the transplant and the degree of protein glycation in the cerebrospinal liquid, which can play a role in unravelling the development of MS. ",

keywords = "Biomarkers, Proteomics, abdominal aorta aneurysm (AAA), Multiple Sclerosis (MS), Donor kidneys",

author = "B. Pulinx",

year = "2012",

month = jan,

day = "1",

doi = "10.26481/dis.20121003bp",

language = "English",

publisher = "Maastricht University",

school = "Maastricht University",

}

TY - BOOK

T1 - Protein biomarkers in chronic disease : proteomics-driven discovery

AU - Pulinx, B.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - For this dissertation proteomics techniques were used to find new/better biomarkers for aneurisms of the abdominal aorta (AAA), Multiple Sclerosis (MS) and the quality of donor kidneys. It is shown that certain proteins in the blood are associated with AAA size and growth, and can be helpful in determining a successful surgical intervention to treat the AAA. Moreover, in the perfusion liquid of donor kidneys proteins were found that are an indication for the vital strength of the transplant and the degree of protein glycation in the cerebrospinal liquid, which can play a role in unravelling the development of MS.

AB - For this dissertation proteomics techniques were used to find new/better biomarkers for aneurisms of the abdominal aorta (AAA), Multiple Sclerosis (MS) and the quality of donor kidneys. It is shown that certain proteins in the blood are associated with AAA size and growth, and can be helpful in determining a successful surgical intervention to treat the AAA. Moreover, in the perfusion liquid of donor kidneys proteins were found that are an indication for the vital strength of the transplant and the degree of protein glycation in the cerebrospinal liquid, which can play a role in unravelling the development of MS.

KW - Biomarkers

KW - Proteomics

KW - abdominal aorta aneurysm (AAA)

KW - Multiple Sclerosis (MS)

KW - Donor kidneys

U2 - 10.26481/dis.20121003bp

DO - 10.26481/dis.20121003bp

M3 - Doctoral Thesis

PB - Maastricht University

CY - Maastricht

ER -

Protein biomarkers in chronic disease : proteomics-driven discovery

Abstract

Keywords

Access to Document

Fingerprint

Cite this