Protein biomarkers in chronic disease : proteomics-driven discovery

B. Pulinx

Research output: ThesisDoctoral ThesisInternal

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Abstract


For this dissertation proteomics techniques were used to find new/better biomarkers for aneurisms of the abdominal aorta (AAA), Multiple Sclerosis (MS) and the quality of donor kidneys. It is shown that certain proteins in the blood are associated with AAA size and growth, and can be helpful in determining a successful surgical intervention to treat the AAA. Moreover, in the perfusion liquid of donor kidneys proteins were found that are an indication for the vital strength of the transplant and the degree of protein glycation in the cerebrospinal liquid, which can play a role in unravelling the development of MS.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Visser - van Dieijen, Marja, Supervisor
  • Schurink, Gerardus, Supervisor
  • Wodzig, Will, Advisor
Award date3 Oct 2012
Place of PublicationMaastricht
Publisher
Publication statusPublished - 1 Jan 2012

Keywords

  • Biomarkers
  • Proteomics
  • abdominal aorta aneurysm (AAA)
  • Multiple Sclerosis (MS)
  • Donor kidneys

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