Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report

Renske J. de Jong, Nicole Paulin, Patricia Lemnitzer, Joana R. Viola, Carla Winter, Bartolo Ferraro, Jochen Grommes, Christian Weber, Chris Reutelingsperger, Maik Drechsler, Oliver Soehnlein*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective-Restenosis as a consequence of arterial injury is aggravated by inflammatory pathways. Here, we investigate the role of the proresolving protein annexin A1 (AnxA1) in healing after wire injury.

Approach and Results-Apoe(-/-) and Apoe(-/-) Anxa1(-/-) mice were subjected to wire injury while fed a high-cholesterol diet. Subsequently, localization of AnxA1 and AnxA1 plasma levels were examined. AnxA1 was found to localize within endothelial cells and macrophages in the neointima. Levels of AnxA1 in the plasma and its lesional expression negatively correlated with neointima size, and in the absence of AnxA1, neointima formation was aggravated by the accumulation and proliferation of macrophages. In contrast, reendothelialization and smooth muscle cell infiltration were not affected in Apoe(-/-) Anxa1(-/-) mice.

Conclusions-AnxA1 is protective in healing after wire injury and could, therefore, be an attractive therapeutic compound to prevent from restenosis after vascular damage.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalArteriosclerosis Thrombosis and Vascular Biology
Issue number2
Publication statusPublished - Feb 2017


  • annexin A1
  • macrophage
  • neointima formation
  • resolution of inflammation


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