Protection of nigral cell death by bilateral subthalamic nucleus stimulation

Y. Temel*, V. Visser-Vandewalle, S. Kaplan, R. Kozan, M.A.R.C. Daemen, A. Blokland, C. Schmitz, H.W. Steinbusch

*Corresponding author for this work

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102 Citations (Web of Science)


In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia. nigra. pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD.
Original languageEnglish
Pages (from-to)100-105
JournalBrain Research
Issue number1
Publication statusPublished - 1 Jan 2006

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