Protection of nigral cell death by bilateral subthalamic nucleus stimulation

Y. Temel; V. Visser-Vandewalle; S. Kaplan; R. Kozan; M.A.R.C. Daemen; A. Blokland; C. Schmitz; H.W. Steinbusch

doi:10.1016/j.brainres.2006.08.082

Protection of nigral cell death by bilateral subthalamic nucleus stimulation

Y. Temel^*, V. Visser-Vandewalle, S. Kaplan, R. Kozan, M.A.R.C. Daemen, A. Blokland, C. Schmitz, H.W. Steinbusch

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia. nigra. pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD.

Original language	English
Pages (from-to)	100-105
Journal	Brain Research
Volume	1120
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2006.08.082
Publication status	Published - 1 Jan 2006

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title = "Protection of nigral cell death by bilateral subthalamic nucleus stimulation",

abstract = "In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia. nigra. pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD. ",

author = "Y. Temel and V. Visser-Vandewalle and S. Kaplan and R. Kozan and M.A.R.C. Daemen and A. Blokland and C. Schmitz and H.W. Steinbusch",

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T1 - Protection of nigral cell death by bilateral subthalamic nucleus stimulation

AU - Temel, Y.

AU - Visser-Vandewalle, V.

AU - Kaplan, S.

AU - Kozan, R.

AU - Daemen, M.A.R.C.

AU - Blokland, A.

AU - Schmitz, C.

AU - Steinbusch, H.W.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia. nigra. pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD.

AB - In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia. nigra. pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD.

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DO - 10.1016/j.brainres.2006.08.082

M3 - Article

C2 - 16999940

SN - 0006-8993

VL - 1120

SP - 100

EP - 105

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Protection of nigral cell death by bilateral subthalamic nucleus stimulation

Abstract

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