Protect us from poor-quality medical research

John P. A. Ioannidis; Siladitya Bhattacharya; J. L. H. Evers; Fulco van der Veen; Edgardo Somigliana; Christopher L. R. Barratt; Gianluca Bontempi; David T. Baird; PierGiorgio Crosignani; Paul Devroey; Klaus Diedrich; Roy G. Farquharson; Lynn R. Fraser; Joep P. M. Geraedts; Luca Gianaroli; Carlo La Vecchia; Kersti Lundin; Cristina Magli; Eva Negri; Arne Sunde; Juha S. Tapanainen; Basil C. Tarlatzis; Andre Van Steirteghem; Anna Veiga; ESHRE Capri Workshop Grp

doi:10.1093/humrep/dey056

Protect us from poor-quality medical research

John P. A. Ioannidis^*, Siladitya Bhattacharya, J. L. H. Evers, Fulco van der Veen, Edgardo Somigliana, Christopher L. R. Barratt, Gianluca Bontempi, David T. Baird, PierGiorgio Crosignani, Paul Devroey, Klaus Diedrich, Roy G. Farquharson, Lynn R. Fraser, Joep P. M. Geraedts, Luca Gianaroli, Carlo La Vecchia, Kersti Lundin, Cristina Magli, Eva Negri, Arne SundeJuha S. Tapanainen, Basil C. Tarlatzis, Andre Van Steirteghem, Anna Veiga, ESHRE Capri Workshop Grp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

Original language	English
Pages (from-to)	770-776
Number of pages	7
Journal	Human Reproduction
Volume	33
Issue number	5
DOIs	https://doi.org/10.1093/humrep/dey056
Publication status	Published - 1 May 2018

Keywords

medical research
randomized clinical trial
meta-analysis
P-value
equipose
RANDOMIZED-TRIALS
BIOMEDICAL-RESEARCH
SYSTEMATIC REVIEWS
REDUCING WASTE
P-VALUES
HEALTH
METAANALYSES
OUTCOMES

Access to Document

10.1093/humrep/dey056

Cite this

Ioannidis, J. P. A., Bhattacharya, S., Evers, J. L. H., van der Veen, F., Somigliana, E., Barratt, C. L. R., Bontempi, G., Baird, D. T., Crosignani, P., Devroey, P., Diedrich, K., Farquharson, R. G., Fraser, L. R., Geraedts, J. P. M., Gianaroli, L., La Vecchia, C., Lundin, K., Magli, C., Negri, E., ... ESHRE Capri Workshop Grp (2018). Protect us from poor-quality medical research. Human Reproduction, 33(5), 770-776. https://doi.org/10.1093/humrep/dey056

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abstract = "Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.",

keywords = "medical research, randomized clinical trial, meta-analysis, P-value, equipose, RANDOMIZED-TRIALS, BIOMEDICAL-RESEARCH, SYSTEMATIC REVIEWS, REDUCING WASTE, P-VALUES, HEALTH, METAANALYSES, OUTCOMES",

author = "Ioannidis, {John P. A.} and Siladitya Bhattacharya and Evers, {J. L. H.} and {van der Veen}, Fulco and Edgardo Somigliana and Barratt, {Christopher L. R.} and Gianluca Bontempi and Baird, {David T.} and PierGiorgio Crosignani and Paul Devroey and Klaus Diedrich and Farquharson, {Roy G.} and Fraser, {Lynn R.} and Geraedts, {Joep P. M.} and Luca Gianaroli and {La Vecchia}, Carlo and Kersti Lundin and Cristina Magli and Eva Negri and Arne Sunde and Tapanainen, {Juha S.} and Tarlatzis, {Basil C.} and {Van Steirteghem}, Andre and Anna Veiga and {ESHRE Capri Workshop Grp}",

year = "2018",

month = may,

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doi = "10.1093/humrep/dey056",

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Ioannidis, JPA, Bhattacharya, S, Evers, JLH, van der Veen, F, Somigliana, E, Barratt, CLR, Bontempi, G, Baird, DT, Crosignani, P, Devroey, P, Diedrich, K, Farquharson, RG, Fraser, LR, Geraedts, JPM, Gianaroli, L, La Vecchia, C, Lundin, K, Magli, C, Negri, E, Sunde, A, Tapanainen, JS, Tarlatzis, BC, Van Steirteghem, A, Veiga, A & ESHRE Capri Workshop Grp 2018, 'Protect us from poor-quality medical research', Human Reproduction, vol. 33, no. 5, pp. 770-776. https://doi.org/10.1093/humrep/dey056

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AU - Ioannidis, John P. A.

AU - Bhattacharya, Siladitya

AU - Evers, J. L. H.

AU - van der Veen, Fulco

AU - Somigliana, Edgardo

AU - Barratt, Christopher L. R.

AU - Bontempi, Gianluca

AU - Baird, David T.

AU - Crosignani, PierGiorgio

AU - Devroey, Paul

AU - Diedrich, Klaus

AU - Farquharson, Roy G.

AU - Fraser, Lynn R.

AU - Geraedts, Joep P. M.

AU - Gianaroli, Luca

AU - La Vecchia, Carlo

AU - Lundin, Kersti

AU - Magli, Cristina

AU - Negri, Eva

AU - Sunde, Arne

AU - Tapanainen, Juha S.

AU - Tarlatzis, Basil C.

AU - Van Steirteghem, Andre

AU - Veiga, Anna

AU - ESHRE Capri Workshop Grp

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

AB - Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

KW - medical research

KW - randomized clinical trial

KW - meta-analysis

KW - P-value

KW - equipose

KW - RANDOMIZED-TRIALS

KW - BIOMEDICAL-RESEARCH

KW - SYSTEMATIC REVIEWS

KW - REDUCING WASTE

KW - P-VALUES

KW - HEALTH

KW - METAANALYSES

KW - OUTCOMES

U2 - 10.1093/humrep/dey056

DO - 10.1093/humrep/dey056

M3 - Article

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SN - 0268-1161

VL - 33

SP - 770

EP - 776

JO - Human Reproduction

JF - Human Reproduction

IS - 5

ER -