Prosthetic Joint Infection Research Models in NZW Rabbits: Opportunities for Standardization-A Systematic Review

Julia L van Agtmaal, Sanne W G van Hoogstraten, Jacobus J C Arts*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Prosthetic joint infection (PJI) is a major complication following total arthroplasty. Rising antimicrobial resistance (AMR) to antibiotics will further increase therapeutic insufficiency. New antibacterial technologies are being developed to prevent PJI. In vivo models are still needed to bridge the translational gap to clinical implementation. Though rabbit models have been used most frequently, there is no consensus about methodology and measured outcomes. The PubMed, Scopus, and EMBASE databases were searched for literature on PJI in rabbit models. Data extraction included bias control, experimental design, and outcome measures of the NZW rabbit models in the articles. A total of 60 articles were included in this systematic literature review. The articles were divided into six groups based on the PJI intervention: no intervention used (21%), revision surgery (14%), prevention with only antibiotics (21%), prevention with surface modifications (7%), prevention with coatings (23%), and others (14%). Despite the current availability of guidelines and recommendations regarding experimental design, bias control, and outcome measures, many articles neglect to report on these matters. Ultimately, this analysis aims to assist researchers in determining suitable clinically relevant methodologies and outcome measures for in vivo PJI models using NZW rabbits to test new antimicrobial technologies.
Original languageEnglish
Article number307
Number of pages85
JournalJournal of Functional Biomaterials
Volume15
Issue number10
DOIs
Publication statusPublished - 15 Oct 2024

Keywords

  • ARRIVE guidelines
  • NZW rabbit
  • antibacterial technologies
  • in vivo
  • prosthetic joint infection

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