Prostate cancer susceptibility genes on 8p21-23 in a Dutch population

M.P.A. Zeegers, D. Nekeman, H.S. Khan, B.A.C. van Dijk, R.A. Goldbohm, J. Schalken, S. Shajahan, A. Pearlman, C. Oddoux, P.A. van den Brandt, L.J. Schouten, H. Ostrer

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Background:Prostate cancer is the most commonly diagnosed cancer in men and the United States. Numerous studies have indicated genetics to have role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have association between prostate cancer and chromosome 8p21-23. In this analysed eight microsatellite (MS) markers in that region in order to previous results and narrow down the location of candidate prostate genes.Methods:292 cases and 278 controls were selected from the Cohort Study (NLCS). The following MSs were used in the analyses: D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. evaluated using a chi2 test and logistic regression. We checked for any on the association by tumour stage.Results:Associations that were found previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (OR), 0.69; P=4.00 x 10-28), and D8S520 (OR, 0.80; P=3.37 x 10-11), were consistently and strongly related with prostate cancer. Genotype an additive effect for D8S136 (P-trend=6.22 x 10-03) and D8S520 (P- 10-22), suggesting an increased risk for people with a short number of both alleles at those markers.Conclusions:This study provides strong that the 8p21-23 region is likely to harbour prostate cancer Cancer and Prostatic Disease advance online publication, 30 April 2013; doi:10.1038/pcan.2013.9.
Original languageEnglish
Pages (from-to)248-253
JournalProstate Cancer and Prostatic Diseases
Issue number3
Publication statusPublished - 1 Jan 2013

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Zeegers, M. P. A., Nekeman, D., Khan, H. S., van Dijk, B. A. C., Goldbohm, R. A., Schalken, J., Shajahan, S., Pearlman, A., Oddoux, C., van den Brandt, P. A., Schouten, L. J., & Ostrer, H. (2013). Prostate cancer susceptibility genes on 8p21-23 in a Dutch population. Prostate Cancer and Prostatic Diseases, 16(3), 248-253.