Prostate cancer susceptibility genes on 8p21-23 in a Dutch population

M.P.A. Zeegers, D. Nekeman, H.S. Khan, B.A.C. van Dijk, R.A. Goldbohm, J. Schalken, S. Shajahan, A. Pearlman, C. Oddoux, P.A. van den Brandt, L.J. Schouten, H. Ostrer

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Abstract

Background:Prostate cancer is the most commonly diagnosed cancer in men and the United States. Numerous studies have indicated genetics to have role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have association between prostate cancer and chromosome 8p21-23. In this analysed eight microsatellite (MS) markers in that region in order to previous results and narrow down the location of candidate prostate genes.Methods:292 cases and 278 controls were selected from the Cohort Study (NLCS). The following MSs were used in the analyses: D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. evaluated using a chi2 test and logistic regression. We checked for any on the association by tumour stage.Results:Associations that were found previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (OR), 0.69; P=4.00 x 10-28), and D8S520 (OR, 0.80; P=3.37 x 10-11), were consistently and strongly related with prostate cancer. Genotype an additive effect for D8S136 (P-trend=6.22 x 10-03) and D8S520 (P- 10-22), suggesting an increased risk for people with a short number of both alleles at those markers.Conclusions:This study provides strong that the 8p21-23 region is likely to harbour prostate cancer Cancer and Prostatic Disease advance online publication, 30 April 2013; doi:10.1038/pcan.2013.9.
Original languageEnglish
Pages (from-to)248-253
JournalProstate Cancer and Prostatic Diseases
Volume16
Issue number3
DOIs
Publication statusPublished - 1 Jan 2013

Cite this

Zeegers, M. P. A., Nekeman, D., Khan, H. S., van Dijk, B. A. C., Goldbohm, R. A., Schalken, J., ... Ostrer, H. (2013). Prostate cancer susceptibility genes on 8p21-23 in a Dutch population. Prostate Cancer and Prostatic Diseases, 16(3), 248-253. https://doi.org/10.1038/pcan.2013.9
Zeegers, M.P.A. ; Nekeman, D. ; Khan, H.S. ; van Dijk, B.A.C. ; Goldbohm, R.A. ; Schalken, J. ; Shajahan, S. ; Pearlman, A. ; Oddoux, C. ; van den Brandt, P.A. ; Schouten, L.J. ; Ostrer, H. / Prostate cancer susceptibility genes on 8p21-23 in a Dutch population. In: Prostate Cancer and Prostatic Diseases. 2013 ; Vol. 16, No. 3. pp. 248-253.
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title = "Prostate cancer susceptibility genes on 8p21-23 in a Dutch population",
abstract = "Background:Prostate cancer is the most commonly diagnosed cancer in men and the United States. Numerous studies have indicated genetics to have role in the aetiology of this disease; as much as 42{\%} of the risk may be explained by heritable factors. Genome-wide association studies have association between prostate cancer and chromosome 8p21-23. In this analysed eight microsatellite (MS) markers in that region in order to previous results and narrow down the location of candidate prostate genes.Methods:292 cases and 278 controls were selected from the Cohort Study (NLCS). The following MSs were used in the analyses: D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. evaluated using a chi2 test and logistic regression. We checked for any on the association by tumour stage.Results:Associations that were found previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (OR), 0.69; P=4.00 x 10-28), and D8S520 (OR, 0.80; P=3.37 x 10-11), were consistently and strongly related with prostate cancer. Genotype an additive effect for D8S136 (P-trend=6.22 x 10-03) and D8S520 (P- 10-22), suggesting an increased risk for people with a short number of both alleles at those markers.Conclusions:This study provides strong that the 8p21-23 region is likely to harbour prostate cancer Cancer and Prostatic Disease advance online publication, 30 April 2013; doi:10.1038/pcan.2013.9.",
author = "M.P.A. Zeegers and D. Nekeman and H.S. Khan and {van Dijk}, B.A.C. and R.A. Goldbohm and J. Schalken and S. Shajahan and A. Pearlman and C. Oddoux and {van den Brandt}, P.A. and L.J. Schouten and H. Ostrer",
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Zeegers, MPA, Nekeman, D, Khan, HS, van Dijk, BAC, Goldbohm, RA, Schalken, J, Shajahan, S, Pearlman, A, Oddoux, C, van den Brandt, PA, Schouten, LJ & Ostrer, H 2013, 'Prostate cancer susceptibility genes on 8p21-23 in a Dutch population', Prostate Cancer and Prostatic Diseases, vol. 16, no. 3, pp. 248-253. https://doi.org/10.1038/pcan.2013.9

Prostate cancer susceptibility genes on 8p21-23 in a Dutch population. / Zeegers, M.P.A.; Nekeman, D.; Khan, H.S.; van Dijk, B.A.C.; Goldbohm, R.A.; Schalken, J.; Shajahan, S.; Pearlman, A.; Oddoux, C.; van den Brandt, P.A.; Schouten, L.J.; Ostrer, H.

In: Prostate Cancer and Prostatic Diseases, Vol. 16, No. 3, 01.01.2013, p. 248-253.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prostate cancer susceptibility genes on 8p21-23 in a Dutch population

AU - Zeegers, M.P.A.

AU - Nekeman, D.

AU - Khan, H.S.

AU - van Dijk, B.A.C.

AU - Goldbohm, R.A.

AU - Schalken, J.

AU - Shajahan, S.

AU - Pearlman, A.

AU - Oddoux, C.

AU - van den Brandt, P.A.

AU - Schouten, L.J.

AU - Ostrer, H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background:Prostate cancer is the most commonly diagnosed cancer in men and the United States. Numerous studies have indicated genetics to have role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have association between prostate cancer and chromosome 8p21-23. In this analysed eight microsatellite (MS) markers in that region in order to previous results and narrow down the location of candidate prostate genes.Methods:292 cases and 278 controls were selected from the Cohort Study (NLCS). The following MSs were used in the analyses: D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. evaluated using a chi2 test and logistic regression. We checked for any on the association by tumour stage.Results:Associations that were found previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (OR), 0.69; P=4.00 x 10-28), and D8S520 (OR, 0.80; P=3.37 x 10-11), were consistently and strongly related with prostate cancer. Genotype an additive effect for D8S136 (P-trend=6.22 x 10-03) and D8S520 (P- 10-22), suggesting an increased risk for people with a short number of both alleles at those markers.Conclusions:This study provides strong that the 8p21-23 region is likely to harbour prostate cancer Cancer and Prostatic Disease advance online publication, 30 April 2013; doi:10.1038/pcan.2013.9.

AB - Background:Prostate cancer is the most commonly diagnosed cancer in men and the United States. Numerous studies have indicated genetics to have role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have association between prostate cancer and chromosome 8p21-23. In this analysed eight microsatellite (MS) markers in that region in order to previous results and narrow down the location of candidate prostate genes.Methods:292 cases and 278 controls were selected from the Cohort Study (NLCS). The following MSs were used in the analyses: D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. evaluated using a chi2 test and logistic regression. We checked for any on the association by tumour stage.Results:Associations that were found previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (OR), 0.69; P=4.00 x 10-28), and D8S520 (OR, 0.80; P=3.37 x 10-11), were consistently and strongly related with prostate cancer. Genotype an additive effect for D8S136 (P-trend=6.22 x 10-03) and D8S520 (P- 10-22), suggesting an increased risk for people with a short number of both alleles at those markers.Conclusions:This study provides strong that the 8p21-23 region is likely to harbour prostate cancer Cancer and Prostatic Disease advance online publication, 30 April 2013; doi:10.1038/pcan.2013.9.

U2 - 10.1038/pcan.2013.9

DO - 10.1038/pcan.2013.9

M3 - Article

VL - 16

SP - 248

EP - 253

JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

SN - 1365-7852

IS - 3

ER -