Prospects of targeted and immune therapies in SCLC

Lizza E. L. Hendriks*, Jessica Menis, Martin Reck

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

9 Citations (Web of Science)
173 Downloads (Pure)

Abstract

Introduction: Small cell lung cancer (SCLC) is a tumor with a poor prognosis, often diagnosed in an advanced stage. Despite aggressive treatment of early and locally advanced disease, SCLC often relapses. First line chemotherapy provides good response rates in advanced disease, but progression free and overall survival are limited. New drugs such as some targeted therapies and immune therapies are promising in SCLC. Areas covered: In this review, we discuss the preclinical rationale and trial data for targeted therapies and immune therapies in SCLC, with a specific focus on clinical trials. Expert commentary: Lack of identification of clear prognostic and predictive biomarkers has limited the advances in treatment efficacy. This has most likely been the main cause of failure for compounds tested so far. Due to the highly mutational profile and the rapid growth pattern of SCLC, immunotherapy combined with chemotherapy seems the most promising treatment option. Concerning targeted agents, achievements made so far are small, but DLL3-antibodies or combinations of PARPi and immunotherapy could be very promising. These promising strategies also need testing in limited disease.

Original languageEnglish
Pages (from-to)151-167
Number of pages17
JournalExpert review of anticancer therapy
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • Checkpoint inhibitors
  • immune therapy
  • small cell lung cancer
  • targeted therapy
  • vaccination therapy
  • CELL-LUNG-CANCER
  • ANTIBODY-DRUG CONJUGATE
  • PERSONALIZED PEPTIDE VACCINATION
  • POTENTIAL THERAPEUTIC TARGET
  • PLACEBO-CONTROLLED TRIAL
  • RANDOMIZED PHASE-II
  • REGULATORY T-CELLS
  • DOUBLE-BLIND
  • AURORA KINASE
  • OPEN-LABEL

Cite this