Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study

Maria H. Kroon; Michaela Diamant; Katja Van Den Hurk; Frans Boomsma; Marjan Alssema; Giel Nijpels; Otto Kamp; Walter J. Paulus; Coen D. A. Stehouwer; Jacqueline M. Dekker; Ronald M. A. Henry

doi:10.2337/dc11-1959

Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study

Maria H. Kroon^*
, Michaela Diamant
, Katja Van Den Hurk
, Frans Boomsma
, Marjan Alssema
, Giel Nijpels
, Otto Kamp
, Walter J. Paulus
, Coen D. A. Stehouwer
, Jacqueline M. Dekker
, Ronald M. A. Henry

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE-Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non-heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS-Echocardiographic measurements were performed at baseline (2000-2001) and follow-up (2007-2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (

Original language	English
Pages (from-to)	2510-2514
Number of pages	5
Journal	Diabetes Care
Volume	35
Issue number	12
DOIs	https://doi.org/10.2337/dc11-1959
Publication status	Published - Dec 2012

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10.2337/dc11-1959Licence: CC BY-NC-ND

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Kroon, M. H., Diamant, M., Van Den Hurk, K., Boomsma, F., Alssema, M., Nijpels, G., Kamp, O., Paulus, W. J., Stehouwer, C. D. A., Dekker, J. M., & Henry, R. M. A. (2012). Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study. Diabetes Care, 35(12), 2510-2514. https://doi.org/10.2337/dc11-1959

@article{31d6e9086fbc46b4b1bcaeda8cbe5a89,

title = "Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study",

abstract = "OBJECTIVE-Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non-heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS-Echocardiographic measurements were performed at baseline (2000-2001) and follow-up (2007-2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32\% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (",

author = "Kroon, \{Maria H.\} and Michaela Diamant and \{Van Den Hurk\}, Katja and Frans Boomsma and Marjan Alssema and Giel Nijpels and Otto Kamp and Paulus, \{Walter J.\} and Stehouwer, \{Coen D. A.\} and Dekker, \{Jacqueline M.\} and Henry, \{Ronald M. A.\}",

year = "2012",

month = dec,

doi = "10.2337/dc11-1959",

language = "English",

volume = "35",

pages = "2510--2514",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "12",

}

Kroon, MH, Diamant, M, Van Den Hurk, K, Boomsma, F, Alssema, M, Nijpels, G, Kamp, O, Paulus, WJ, Stehouwer, CDA, Dekker, JM & Henry, RMA 2012, 'Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study', Diabetes Care, vol. 35, no. 12, pp. 2510-2514. https://doi.org/10.2337/dc11-1959

Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study. / Kroon, Maria H.; Diamant, Michaela; Van Den Hurk, Katja et al.
In: Diabetes Care, Vol. 35, No. 12, 12.2012, p. 2510-2514.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study

AU - Kroon, Maria H.

AU - Diamant, Michaela

AU - Van Den Hurk, Katja

AU - Boomsma, Frans

AU - Alssema, Marjan

AU - Nijpels, Giel

AU - Kamp, Otto

AU - Paulus, Walter J.

AU - Stehouwer, Coen D. A.

AU - Dekker, Jacqueline M.

AU - Henry, Ronald M. A.

PY - 2012/12

Y1 - 2012/12

N2 - OBJECTIVE-Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non-heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS-Echocardiographic measurements were performed at baseline (2000-2001) and follow-up (2007-2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (

AB - OBJECTIVE-Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non-heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS-Echocardiographic measurements were performed at baseline (2000-2001) and follow-up (2007-2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (

U2 - 10.2337/dc11-1959

DO - 10.2337/dc11-1959

M3 - Article

C2 - 23033248

SN - 0149-5992

VL - 35

SP - 2510

EP - 2514

JO - Diabetes Care

JF - Diabetes Care

IS - 12

ER -

Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study

Abstract

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