Prospective Associations of B-Type Natriuretic Peptide With Markers of Left Ventricular Function in Individuals With and Without Type 2 Diabetes An 8-year follow-up of the Hoorn Study

Maria H. Kroon*, Michaela Diamant, Katja Van Den Hurk, Frans Boomsma, Marjan Alssema, Giel Nijpels, Otto Kamp, Walter J. Paulus, Coen D. A. Stehouwer, Jacqueline M. Dekker, Ronald M. A. Henry

*Corresponding author for this work

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OBJECTIVE-Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non-heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS-Echocardiographic measurements were performed at baseline (2000-2001) and follow-up (2007-2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (
Original languageEnglish
Pages (from-to)2510-2514
JournalDiabetes Care
Issue number12
Publication statusPublished - Dec 2012

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